| Partitioning of exhaled NO in ventilated patients undergoing cardiac surgery. | |
| | |
MedLine Citation:
|
PMID: 20219698 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The change in exhaled NO after cardio-pulmonary bypass remains controversial. The aims were to determine whether exhaled NO sources (alveolar or bronchial) are modified after bypass, and whether mechanical ventilation (MV) settings during bypass modify exhaled NO changes. Thirty-two patients were divided into three groups: without MV during bypass and positive end-expiratory pressure (PEEP) (n=12), dead space MV without PEEP (n=10) and dead space MV with PEEP (n=10). Alveolar NO concentration and bronchial NO flux were calculated before and 1h after surgery using a two-compartment model of NO exchange developed in spontaneous breathing patients. Whereas a significant decrease in bronchial NO was found after bypass in the two groups without PEEP during bypass, this decrease was not observed in patients with dead space ventilation with PEEP. Alveolar NO was not significantly modified whatever the ventilation settings. In conclusion, the impairment of bronchial NO seemed related to airway closure since dead space mechanical ventilation with PEEP prevented its decrease. |
| | |
Authors:
|
Jean-Marc Tadié; Rachid Zegdi; Ludovic Trinquart; Okba Kurdi; Didier Journois; Christian Latremouille; Jean-Luc Diehl; Bruno Louis; Jean-Yves Fagon; Jean-Noël Fabiani; Christophe Delclaux |
Related Documents
:
|
10809308 - Use of recruitment maneuvers and high-positive end-expiratory pressure in a patient wit... 12168368 - Effects of positive end-expiratory pressure on intracranial pressure and cerebral perfu... 17194318 - Setting positive end-expiratory pressure during jet ventilation to replicate the mean a... 8173778 - Should inverse ratio ventilation be used in adult respiratory distress syndrome? 10710578 - Evaluation of computer based clinical decision support system and risk chart for manage... 22092208 - Effect of patient position and peep on hepatic, portal and central venous pressures dur... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-02-26 |
Journal Detail:
|
Title: Respiratory physiology & neurobiology Volume: 171 ISSN: 1878-1519 ISO Abbreviation: Respir Physiol Neurobiol Publication Date: 2010 Apr |
Date Detail:
|
Created Date: 2010-04-23 Completed Date: 2010-10-28 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101140022 Medline TA: Respir Physiol Neurobiol Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 151-6 Citation Subset: IM |
Copyright Information:
|
(c) 2010 Elsevier B.V. All rights reserved. |
Affiliation:
|
Université Paris Descartes, Paris, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Biological Markers / analysis Bronchi / metabolism* Cardiac Surgical Procedures* Cardiopulmonary Bypass / adverse effects* Exhalation* Female Humans Lung Injury / etiology, metabolism* Male Middle Aged Nitric Oxide / analysis* Positive-Pressure Respiration / methods Pulmonary Alveoli / metabolism* Respiration, Artificial / methods Respiratory Dead Space |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 10102-43-9/Nitric Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Immunoactive effects of cannabinoids: Considerations for the therapeutic use of cannabinoid receptor...
Next Document: A paradigm shift in imaging for renal colic- Is it time to say good bye to an old trusted friend?