Document Detail

Partitioning of exhaled NO in ventilated patients undergoing cardiac surgery.
MedLine Citation:
PMID:  20219698     Owner:  NLM     Status:  MEDLINE    
The change in exhaled NO after cardio-pulmonary bypass remains controversial. The aims were to determine whether exhaled NO sources (alveolar or bronchial) are modified after bypass, and whether mechanical ventilation (MV) settings during bypass modify exhaled NO changes. Thirty-two patients were divided into three groups: without MV during bypass and positive end-expiratory pressure (PEEP) (n=12), dead space MV without PEEP (n=10) and dead space MV with PEEP (n=10). Alveolar NO concentration and bronchial NO flux were calculated before and 1h after surgery using a two-compartment model of NO exchange developed in spontaneous breathing patients. Whereas a significant decrease in bronchial NO was found after bypass in the two groups without PEEP during bypass, this decrease was not observed in patients with dead space ventilation with PEEP. Alveolar NO was not significantly modified whatever the ventilation settings. In conclusion, the impairment of bronchial NO seemed related to airway closure since dead space mechanical ventilation with PEEP prevented its decrease.
Jean-Marc Tadié; Rachid Zegdi; Ludovic Trinquart; Okba Kurdi; Didier Journois; Christian Latremouille; Jean-Luc Diehl; Bruno Louis; Jean-Yves Fagon; Jean-Noël Fabiani; Christophe Delclaux
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-26
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  171     ISSN:  1878-1519     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-23     Completed Date:  2010-10-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  151-6     Citation Subset:  IM    
Copyright Information:
(c) 2010 Elsevier B.V. All rights reserved.
Université Paris Descartes, Paris, France.
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MeSH Terms
Aged, 80 and over
Biological Markers / analysis
Bronchi / metabolism*
Cardiac Surgical Procedures*
Cardiopulmonary Bypass / adverse effects*
Lung Injury / etiology,  metabolism*
Middle Aged
Nitric Oxide / analysis*
Positive-Pressure Respiration / methods
Pulmonary Alveoli / metabolism*
Respiration, Artificial / methods
Respiratory Dead Space
Reg. No./Substance:
0/Biological Markers; 10102-43-9/Nitric Oxide

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