| Partition of oleic acid between the lymph and portal blood in rats having a diverted bile-pancreatic duct. | |
| | |
MedLine Citation:
|
PMID: 8785202 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The present study examines the suggestion that in the absence of adequate bile and pancreatic juice, which support the absorption from the gut of long-chain fatty acids into lymph, the fatty acids are absorbed directly into the portal blood. Oleic acid (18:1) partitioning between lymph and portal blood was investigated in intact and bile- and pancreatic juice-diverted rats. In a first set of experiments, 18:1 absorption from the gut into lymph and blood was studied by continuous recovery of the mesenteric lymph for 6 h and mesenteric portal venous blood for 1 h. In a second set of experiments, esterification processes were investigated by study of the mucosal distribution of labelled lipids and by mono- and diacylglycerol acyltransferase (EC 2.3.1.22 and EC 2.3.1.20 respectively) specific activities. In the bile- and pancreatic juice-diverted rats the absorption of labelled 18:1 into lymph was significantly reduced during the first 3 h of intraluminal infusion of this substrate. In such rats a compensatory absorption of labelled 18:1 into mesenteric portal blood was not observed. At 6 h after micellar lipid-mixture infusion, the overload of lipids both in free form and as triacylglycerols persisting in the mucosa paralleled the lower acyltransferase specific activities observed in bile- and pancreatic juice-diverted rats. These studies demonstrate the absence of a previously proposed compensatory absorption of 18:1 into portal blood when absorption into lymph is impaired by an inadequate supply of bile and pancreatic juice. |
| | |
Authors:
|
Y Mathieu; C Caselli; A Bernard; H Carlier |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The British journal of nutrition Volume: 75 ISSN: 0007-1145 ISO Abbreviation: Br. J. Nutr. Publication Date: 1996 Feb |
Date Detail:
|
Created Date: 1996-09-20 Completed Date: 1996-09-20 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 249-61 Citation Subset: IM |
Affiliation:
|
Département de Nutrition, Université de Bourgogne, Dijon, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Bile / metabolism* Diglycerides / metabolism Glycerides / metabolism Intestinal Absorption Intestinal Mucosa / metabolism Liver Circulation* Lymph / metabolism* Male Oleic Acids / blood, pharmacokinetics* Pancreatic Juice / metabolism* Rats Rats, Wistar Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Diglycerides; 0/Glycerides; 0/Oleic Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Protein utilization, growth and survival in essential-fatty-acid-deficient rats.
Next Document: In vitro fermentation by human faecal bacteria of total and purified dietary fibres from brown seawe...