| Partition coefficients for nonane and its isomers in the rat. | |
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MedLine Citation:
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PMID: 20919799 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Jet Fuel 8 (JP-8) is a major fuel source used by US and NATO military. JP-8 is a complex mixture of aliphatic and aromatic isomers of hydrocarbons. Tissue/blood partition coefficient (PC) values are chemical-specific parameters used in modeling the kinetic behavior of chemicals. The partition coefficient values for n-alkanes tend to increase with the increasing carbon number, but less is known about the trend for isomers of n-alkanes. PC values were obtained for the n-alkane nonane (C9) and five of its isomers, namely 3-methyloctane, 4-ethylheptane, 2,3-dimethylheptane, 2,2,4-trimethylhexane, 2,2,4,4-tetramethylpentane. The blood:air and tissue:air PC values correlated with the published log octanol/water (O:W) PC values for n-nonane and its isomers. Experimentally determined blood:air and tissue:air PC values for n-nonane with the largest O:W value were greatest and smallest for the isomer 2,2,4,4-tetramethylpentane with the lowest O:W value. As expected the fat tissue had the highest PC values and muscle the lowest for n-nonane and its isomers. For each tissue, a linear relationship was observed between the tissue/blood PC values for the isomers of n-nonane and n-nonane. This suggests that tissue/blood PC values for all isomers of an alkane could be estimated using data collected from only a sub-set of alkanes of equal carbon number. These reported tissue/blood PC values will support the development of a jet fuel physiologically-based pharmacokinetic (PBPK) model. |
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Authors:
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G Joshi; R T Tremblay; S A Martin; J W Fisher |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-10-04 |
Journal Detail:
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Title: Toxicology mechanisms and methods Volume: 20 ISSN: 1537-6524 ISO Abbreviation: Toxicol. Mech. Methods Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-22 Completed Date: 2011-02-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101134521 Medline TA: Toxicol Mech Methods Country: England |
Other Details:
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Languages: eng Pagination: 594-9 Citation Subset: IM |
Affiliation:
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College of Public Health, Department of Environmental Health Science, University of Georgia, Athens, Georgia, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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metabolism Alkanes / blood, chemistry, pharmacokinetics* Animals Hydrocarbons / blood, chemistry, pharmacokinetics* Isomerism Male Models, Biological Models, Chemical Rats Rats, Inbred F344 |
| Chemical | |
Reg. No./Substance:
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0/Alkanes; 0/Hydrocarbons; 0/JP8 aviation fuel; 111-84-2/nonane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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