Document Detail

Particulate matter and lung function growth in children: a 3-yr follow-up study in Austrian schoolchildren.
MedLine Citation:
PMID:  12030722     Owner:  NLM     Status:  MEDLINE    
The effects of particulate matter <10 microm in diameter (PM10) and other air pollutants on lung function were assessed in 975 schoolchildren, from eight communities in Lower Austria between 1994-1997. In each community, air pollution data were collected. Spirometry was performed twice a year. PM10 concentration (mean concentration between two subsequent lung-function measures in spring and autumn (summer interval) or between autumn and spring (winter interval)) showed a mean value of 17.36 microg x m(-3) in the summer interval and 21.03 microg m(-3) in the winter interval. A slower increase in the forced expiratory volume in one second (FEV1) and midexpiratory flow between 25 and 75% of the forced vital capacity (MEF25-75) with age in children exposed to higher summer PM10 was observed in the 3-yr study period. After adjusting for potential confounders (sex, atopy, passive smoking, initial height, height difference, site, initial lung function) an increase of summer PM10 by 10 microg x m(-3) was associated with a decrease in FEV1 growth of 84 mL x yr(-1) and 329 mL x s(-1) x yr(-1) for MEF25-75. Nitrogen dioxide and ozone also showed a negative effect on lung-function growth, confirming previous work. The authors concluded that long-term exposure to particulate matter <10 microm in diameter had a significant negative effect on lung-function proxy for the development of large (forced expiratory volume in one second) and small (midexpiratory flow between 25 and 75% of the forced vital capacity) airways, respectively, with strong evidence for a further effect of ozone and nitrogen dioxide on the development of forced vital capacity and forced expiratory volume in one second.
F Horak; M Studnicka; C Gartner; J D Spengler; E Tauber; R Urbanek; A Veiter; T Frischer
Publication Detail:
Type:  Journal Article; Multicenter Study    
Journal Detail:
Title:  The European respiratory journal     Volume:  19     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-05-27     Completed Date:  2002-12-03     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  838-45     Citation Subset:  IM    
University Children's Hospital, Vienna, Austria.
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MeSH Terms
Air Pollutants / adverse effects*
Air Pollution / adverse effects*
Cohort Studies
Longitudinal Studies
Lung / growth & development*
Lung Diseases / etiology*
Particle Size
Prospective Studies
Respiratory Mechanics / drug effects*
Reg. No./Substance:
0/Air Pollutants; 0/Dust
Comment In:
Eur Respir J. 2002 Nov;20(5):1354-5; author reply 1355   [PMID:  12449193 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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