| Particulate air pollution and fetal health: a systematic review of the epidemiologic evidence. | |
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MedLine Citation:
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PMID: 14712145 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Research on the potential impact of air pollution on the health of adults and children has grown rapidly over the last decade. Recent studies have suggested that air pollution could also be associated with adverse effects on the developing fetus. This systematic review evaluates the current level of epidemiologic evidence on the association between ambient particulate air pollution and fetal health outcomes. We also suggest further research questions. METHODS: Using database searches and other approaches, we identified relevant publications published between 1966 and 2001 in English. Articles were included if they reported original data on birthweight, gestational age at delivery, or stillbirth related to directly measured nonaccidental exposure to particulate matter. RESULTS: Twelve studies met the inclusion criteria. There was little consistency in the evidence linking particulate air pollution and fetal outcomes. Many studies had methodologic weaknesses in their design and adjustment for confounding factors. Even in well-designed studies, the reported magnitude of the effects was small and inconsistently associated with exposure at specific stages of pregnancy. CONCLUSIONS: The currently available evidence is compatible with either a small adverse effect of particulate air pollution on fetal growth and duration of pregnancy or with no effect. Further research should be directed toward clarifying and quantifying these possible effects and generating testable hypotheses on plausible biologic mechanisms. |
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Authors:
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Svetlana V Glinianaia; Judith Rankin; Ruth Bell; Tanja Pless-Mulloli; Denise Howel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Epidemiology (Cambridge, Mass.) Volume: 15 ISSN: 1044-3983 ISO Abbreviation: Epidemiology Publication Date: 2004 Jan |
Date Detail:
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Created Date: 2004-01-08 Completed Date: 2004-03-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9009644 Medline TA: Epidemiology Country: United States |
Other Details:
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Languages: eng Pagination: 36-45 Citation Subset: IM |
Affiliation:
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School of Population and Health Sciences, Faculty of Medical Sciences, University of Newcastle, Newcastle-upon-Tyne, United Kigndom. svetlana.glinianaia@ncl.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Air Pollutants / adverse effects* Embryonic and Fetal Development Epidemiologic Studies Female Fetal Growth Retardation / etiology* Humans Infant Welfare* Infant, Newborn Infant, Premature Maternal Exposure* Obstetric Labor, Premature Particle Size Pregnancy Pregnancy Outcome / epidemiology* Risk Assessment |
| Chemical | |
Reg. No./Substance:
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0/Air Pollutants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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