Document Detail


Particulate matter containing environmentally persistent free radicals and adverse infant respiratory health effects: a review.
MedLine Citation:
PMID:  23281110     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The health impacts of airborne particulate matter (PM) are of global concern, and the direct implications to the development/exacerbation of lung disease are immediately obvious. Most studies to date have sought to understand mechanisms associated with PM exposure in adults/adult animal models; however, infants are also at significant risk for exposure. Infants are affected differently than adults due to drastic immaturities, both physiologically and immunologically, and it is becoming apparent that they represent a critically understudied population. Highlighting our work funded by the ONES award, in this review we argue the understated importance of utilizing infant models to truly understand the etiology of PM-induced predisposition to severe, persistent lung disease. We also touch upon various mechanisms of PM-mediated respiratory damage, with a focus on the emerging importance of environmentally persistent free radicals (EPFRs) ubiquitously present in combustion-derived PM. In conclusion, we briefly comment on strengths/challenges facing current PM research, while giving perspective on how we may address these challenges in the future.
Authors:
Jordy Saravia; Greg I Lee; Slawo Lomnicki; Barry Dellinger; Stephania A Cormier
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-12-20
Journal Detail:
Title:  Journal of biochemical and molecular toxicology     Volume:  27     ISSN:  1099-0461     ISO Abbreviation:  J. Biochem. Mol. Toxicol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-21     Completed Date:  2013-08-02     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  9717231     Medline TA:  J Biochem Mol Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  56-68     Citation Subset:  IM    
Copyright Information:
© 2012 Wiley Periodicals, Inc.
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MeSH Terms
Descriptor/Qualifier:
Air Pollutants / analysis,  toxicity*
Asthma / chemically induced
Free Radicals / analysis,  toxicity*
Humans
Infant
Infant Welfare*
Lung / drug effects,  immunology
Lung Diseases / chemically induced,  immunology
Oxidative Stress
Particulate Matter / toxicity*
Grant Support
ID/Acronym/Agency:
AA007577/AA/NIAAA NIH HHS; P42 ES013648/ES/NIEHS NIH HHS; P42ES013648/ES/NIEHS NIH HHS; R01 ES015050/ES/NIEHS NIH HHS; R01ES015050/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Air Pollutants; 0/Free Radicals; 0/Particulate Matter
Comments/Corrections

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