| Particle-image velocimetry study of a pediatric ventricular assist device. | |
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MedLine Citation:
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PMID: 20590282 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Particle-image velocimetry (PIV) was used to visualize the flow within an optically transparent pediatric ventricular assist device (PVAD) under development in our laboratory. The device studied is a diaphragm type pulsatile pump with an ejection volume of 30 ml per beating cycle intended for temporary cardiac assistance as a bridge to transplantation or recovery in children. Of particular interest was the identification of flow patterns, including regions of stagnation and/or strong turbulence that often promote thrombus formation and hemolysis, which can degrade the usefulness of such devices. For this purpose, phase-locked PIV measurements were performed in planes parallel to the diaphragm that drives the flow in the device. The test fluid was seeded with 10 microm polystyrene spheres, and the motion of these particles was used to determine the instantaneous flow velocity distribution in the illumination plane. These measurements revealed that flow velocities up to 1.0 m/s can occur within the PVAD. Phase-averaged velocity fields revealed the fixed vortices that drive the bulk flow within the device, though significant cycle-to-cycle variability was also quite apparent in the instantaneous velocity distributions, most notably during the filling phase. This cycle-to-cycle variability can generate strong turbulence that may contribute to greater hemolysis. Stagnation regions have also been observed between the input and output branches of the prototype, which can increase the likelihood of thrombus formation. |
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Authors:
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E Ferrara; M Muramatsu; K T Christensen; I A Cestari |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of biomechanical engineering Volume: 132 ISSN: 1528-8951 ISO Abbreviation: J Biomech Eng Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-01 Completed Date: 2010-10-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7909584 Medline TA: J Biomech Eng Country: United States |
Other Details:
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Languages: eng Pagination: 071004 Citation Subset: IM |
Affiliation:
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Optics Group, Physics Institute, University of São Paulo, São Paulo, SP Brazil. eferrara@if.usp.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Child Heart Ventricles Heart-Assist Devices* Hemolysis Humans Rheology / instrumentation* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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