Document Detail

Particle Trajectories and Agglomeration/Accumulation in Branching Arteries subjected to Orbital Atherectomy.
MedLine Citation:
PMID:  21643425     Owner:  NLM     Status:  PubMed-not-MEDLINE    
BACKGROUND: The transport of particles in surrogate and actual arterial geometries has been investigated synergistically by experimentation and numerical simulation. The motivating application for this work is orbital atherectomy which spawns a particle cloud in the process of debulking plaque from arterial walls.
METHODS: Paired simulations and experiments were performed to prove the capability of the simulation model to predict both fluid and particle motions in branched arterial geometries. The verified model was then employed to predict the pattern of fluid flow in an actual multi-branched arterial geometry, including the flowrates passing through each of the individual branches. These predictions are in very good agreement with experimental data. Focus was then shifted to the issues of particle agglomeration within the flowing fluid and particle accumulation on the vessel walls. Once again, a synergistic approach was used. Flow visualization was employed to track the particle motions and to identify possible particle agglomeration within the fluid.
RESULTS AND CONCLUSIONS: Accumulation of particles on walls was identified by measuring size distributions of effluent and residue within the artery. Scanning Electron Microscopy (SEM) evaluation showed evidence of a size-based sorting as the particles passed through vessels. It was found that plaque-facsimile particles resisted particle-particle agglomeration. They also did not accumulate to the wall of the facsimile artery. In addition, simulations showed that if particle-wall accumulation were to occur, it would be limited to very small regions in the artery branches.
Zach L Helgeson; Jed S Jenkins; John P Abraham; Ephraim M Sparrow
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Publication Detail:
Type:  Journal Article     Date:  2011-03-22
Journal Detail:
Title:  The open biomedical engineering journal     Volume:  5     ISSN:  1874-1207     ISO Abbreviation:  Open Biomed Eng J     Publication Date:  2011  
Date Detail:
Created Date:  2011-06-06     Completed Date:  2011-07-14     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101507900     Medline TA:  Open Biomed Eng J     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  25-38     Citation Subset:  -    
Laboratory for Heat Transfer and Fluid Flow Practice, University of St. Thomas, St. Paul, MN, USA, 55105-1079.
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