Document Detail

Participation in maternal serum screening following screen positive results in a previous pregnancy.
MedLine Citation:
PMID:  10807139     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether women who have had a positive serum screening result in one pregnancy have a lower rate of participation in screening in their next pregnancy. SETTING: The Women and Infants Hospital triple marker screening programme. METHODS: Pregnancy and screening information was collected from laboratory and hospital databases to compare subsequent screening participation in women who were screen negative and screen positive for risk of Down's syndrome (DS) or neural tube defect (NTD) pregnancy. RESULTS: In an age matched comparison, 108 women who had a previous screen positive result were significantly less likely than 108 women who were screen negative to participate in maternal serum screening in their next pregnancy. When examined according to type of screen positive result, the effect was significant for both those who were screen positive for DS and those who were screen positive for NTD. The degree of risk in screen positive women did not significantly affect their uptake of screening in the next pregnancy. CONCLUSIONS: Anxiety related to a screen positive result probably causes decreased participation in maternal serum screening in the next pregnancy. Reducing the screen positive rate in prenatal serum screening would alleviate maternal anxiety and would probably lead to more stable participation.
D N Rausch; G M Lambert-Messerlian; J A Canick
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of medical screening     Volume:  7     ISSN:  0969-1413     ISO Abbreviation:  J Med Screen     Publication Date:  2000  
Date Detail:
Created Date:  2000-08-02     Completed Date:  2000-08-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9433359     Medline TA:  J Med Screen     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  4-6     Citation Subset:  IM    
Department of Pathology and Laboratory Medicine, Women and Infants Hospital, Brown University School of Medicine, Providence, RI 02905, USA.
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MeSH Terms
Biological Markers / blood*
Case-Control Studies
Chorionic Gonadotropin / blood
Down Syndrome / diagnosis
Estriol / blood
Evaluation Studies as Topic
Mass Screening / methods,  psychology,  statistics & numerical data*
Maternal Age
Neural Tube Defects / diagnosis
Patient Participation*
Prenatal Diagnosis / methods*,  psychology
alpha-Fetoproteins / analysis
Reg. No./Substance:
0/Biological Markers; 0/Chorionic Gonadotropin; 0/alpha-Fetoproteins; 50-27-1/Estriol

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