Document Detail

Participation of arterial baroreceptors input and peripheral vasopressin in the suppression of renal sympathetic nerve activity induced by central salt loading in conscious rats.
MedLine Citation:
PMID:  10412831     Owner:  NLM     Status:  MEDLINE    
We examined whether renal sympathetic nerve activity (RSNA) is suppressed in response to intracerebroventricular (i.c.v.) administration of hypertonic saline (HS) in conscious rats. RSNA was suppressed by i.c.v. administration of HS (0.3 M, 0.67 M, and 1.0 M, 1 microl/min for 20 min) in a concentration-dependent manner, which was attenuated under pentobarbital anesthesia. To elucidate mechanisms responsible for central HS-induced decrease in RSNA, possible involvement of arterial baroreceptors and peripheral arginine vasopressin (AVP) secreted from the posterior pituitary gland was examined using sinoaortic denervated (SAD) rats and non-peptide vasopressin receptor antagonists. The maximum suppression of RSNA (-81.5 +/- 5.5%) in control rats was significantly attenuated to -32.5 +/- 6.7% in SAD rats and to -55.8 +/- 5.7% in rats pretreated with intravenous vasopressin V1 receptor antagonist, OPC-21268 (5 mg/kg, i.v.). However, in SAD rats, pretreatment with vasopressin V1 receptor antagonist did not further affect the RSNA inhibition induced by central salt loading. The results suggest that the suppression of RSNA during central salt loading is mainly dependent on the arterial baroreceptors input and the 'additive' role of peripheral vasopressin.
K Kato; T Shirasaka; T Kunitake; T Hanamori; H Kannan
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the autonomic nervous system     Volume:  76     ISSN:  0165-1838     ISO Abbreviation:  J. Auton. Nerv. Syst.     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-09-01     Completed Date:  1999-09-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8003419     Medline TA:  J Auton Nerv Syst     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  83-92     Citation Subset:  IM    
Department of Physiology, Miyazaki Medical College, Japan.
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MeSH Terms
Arteries / drug effects,  innervation*
Blood Pressure / drug effects,  physiology
Heart Rate / drug effects,  physiology
Injections, Intraventricular
Kidney / innervation*,  physiology
Pressoreceptors / drug effects,  physiology*
Rats, Sprague-Dawley
Receptors, Vasopressin / antagonists & inhibitors
Saline Solution, Hypertonic
Sinoatrial Node / physiology
Sympathetic Nervous System / drug effects,  physiology*
Vasopressins / antagonists & inhibitors,  physiology*
Reg. No./Substance:
0/Receptors, Vasopressin; 0/Saline Solution, Hypertonic; 11000-17-2/Vasopressins

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