Document Detail


Partially polyurethane-covered stent for cerebral aneurysm treatment.
MedLine Citation:
PMID:  18837459     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Partially polyurethane-covered stent (PPCS) is proposed for the treatment of cerebral aneurysms. The PPCSs were observed to substantially modify the flow entering the aneurysm in a patient-specific aneurysm phantom (PSAP). These stents can act as flow modulators and the polyurethane (PU) membrane can provide a smooth scaffold for restoring the structural integrity of the diseased vessel. Partial coating of the stent aids in sealing only the entrance to the aneurysm while keeping the perforators around the aneurysm open and patent. Biocompatibility of the PU membrane was monitored using contact angle measurements to show that critical surface tension (CST) values remained in the thromboresistant range of 20-30 mN/m. Stent flexibility, stiffness, and pressure-diameter relationship showed no significant change after asymmetric PU film application. No delamination of the PU membrane from the stent was observed within the working strains of the stent. The flow modulating capability of the PPCS was monitored by intentionally orienting the stent to cover either the proximal or the distal regions along the neck of the PSAP. Time density curves (TDCs) compared the relative metrics of input rate, washout rate, residence time, and influx in the aneurysm before and after the stent placement.
Authors:
Hussain S Rangwala; Ciprian N Ionita; Stephen Rudin; Robert E Baier
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of biomedical materials research. Part B, Applied biomaterials     Volume:  89     ISSN:  1552-4981     ISO Abbreviation:  J. Biomed. Mater. Res. Part B Appl. Biomater.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-08     Completed Date:  2009-07-02     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  101234238     Medline TA:  J Biomed Mater Res B Appl Biomater     Country:  United States    
Other Details:
Languages:  eng     Pagination:  415-29     Citation Subset:  IM    
Copyright Information:
(c) 2008 Wiley Periodicals, Inc.
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MeSH Terms
Descriptor/Qualifier:
Blood Vessel Prosthesis Implantation
Coated Materials, Biocompatible / chemistry
Elasticity
Humans
Intracranial Aneurysm / surgery*
Materials Testing
Models, Anatomic
Pliability
Polyurethanes / chemistry*
Prosthesis Design
Regional Blood Flow
Stents*
Grant Support
ID/Acronym/Agency:
R01 EB002873/EB/NIBIB NIH HHS; R01 EB002873/EB/NIBIB NIH HHS; R01 EB002873-05/EB/NIBIB NIH HHS; R01 EB002916/EB/NIBIB NIH HHS; R01 EB002916-04/EB/NIBIB NIH HHS; R01 EB02916/EB/NIBIB NIH HHS; R01 NS043924/NS/NINDS NIH HHS; R01 NS043924-04/NS/NINDS NIH HHS; R01 NS43024/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Coated Materials, Biocompatible; 0/Polyurethanes
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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