| Partial tripolar cochlear implant stimulation: Spread of excitation and forward masking in the inferior colliculus. | |
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MedLine Citation:
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PMID: 20727397 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study examines patterns of neural activity in response to single biphasic electrical pulses, presented alone or following a forward masking pulse train, delivered by a cochlear implant. Recordings were made along the tonotopic axis of the central nucleus of the inferior colliculus (ICC) in ketamine/xylazine anesthetized guinea pigs. The partial tripolar electrode configuration was used, which provided a systematic way to vary the tonotopic extent of ICC activation between monopolar (broad) and tripolar (narrow) extremes while maintaining the same peak of activation. The forward masking paradigm consisted of a 200 ms masker pulse train (1017 pulses per second) followed 10 ms later by a single-pulse probe stimulus; the current fraction of the probe was set to 0 (monopolar), 1 (tripolar), or 0.5 (hybrid), and the fraction of the masker was fixed at 0.5. Forward masking tuning profiles were derived from the amount of masking current required to just suppress the activity produced by a fixed-level probe. These profiles were sharper for more focused probe configurations, approximating the pattern of neural activity elicited by single (non-masked) pulses. The result helps to bridge the gap between previous findings in animals and recent psychophysical data. |
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Authors:
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Julie Arenberg Bierer; Steven M Bierer; John C Middlebrooks |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-08-18 |
Journal Detail:
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Title: Hearing research Volume: 270 ISSN: 1878-5891 ISO Abbreviation: Hear. Res. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-06 Completed Date: 2011-03-21 Revised Date: 2011-12-21 |
Medline Journal Info:
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Nlm Unique ID: 7900445 Medline TA: Hear Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 134-42 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Speech and Hearing Sciences, University of Washington, WA 98105, USA. jbierer@u.washington.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acoustic Stimulation Animals Auditory Pathways / physiology* Auditory Perception* Auditory Threshold Cochlear Implants* Electric Stimulation Guinea Pigs Inferior Colliculi / physiology* Perceptual Masking* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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P30 DC004661-11/DC/NIDCD NIH HHS; P30 DC04661/DC/NIDCD NIH HHS; R01 DC004312-05/DC/NIDCD NIH HHS; R01-DC04312/DC/NIDCD NIH HHS; R03 DC008883-03/DC/NIDCD NIH HHS; R03 DC8883/DC/NIDCD NIH HHS |
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