Document Detail


Partial splenic embolization using polyvinyl alcohol foam, dextran, polystyrene, or silicone. An experimental study in dogs.
MedLine Citation:
PMID:  6172809     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Partial splenic arterial embolization (50% reduction in flow) was evaluated in dogs using polyvinyl alcohol foam or microspheres (20-500 mu) made of dextran, polystyrene, or silicone. Dextran and polystyrene were found to be superior for several reasons: they were easier to use, did not shatter when agitated, and produced permanent, homogeneous, peripheral occlusion with only one administration. Partial embolization with dextran or polystyrene increased platelet levels within 1 week and markedly reduced splenic size with minimal if any collateral filling within 6 weeks. Microscopically, no acute infarction or necrosis was seen at 6 weeks; there was some fibrosis, but the remaining parenchyma appeared normal.
Authors:
K C Wright; J H Anderson; C Gianturco; S Wallace; V P Chuang
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Radiology     Volume:  142     ISSN:  0033-8419     ISO Abbreviation:  Radiology     Publication Date:  1982 Feb 
Date Detail:
Created Date:  1982-03-22     Completed Date:  1982-03-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  351-4     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Anion Exchange Resins*
Dextrans*
Dogs
Embolization, Therapeutic*
Gels*
Hypersplenism / therapy
Ion Exchange Resins*
Microspheres
Platelet Count
Polyvinyls*
Resins, Synthetic
Silicones*
Splenic Artery*
Grant Support
ID/Acronym/Agency:
K04-CA-0083-05 RAD/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Anion Exchange Resins; 0/Gels; 0/Ion Exchange Resins; 0/Polyvinyls; 0/Resins, Synthetic; 0/Silicones; 0/ivalon sponge; 37199-22-7/Dowex; 56087-11-7/dextranomer; 9004-54-0/Dextrans; 9014-76-0/sephadex

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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