Document Detail

Partial splenic embolisation for hypersplenism of thalassaemia major: five year follow up.
MedLine Citation:
PMID:  3105679     Owner:  NLM     Status:  MEDLINE    
Six patients with thalassaemia major were treated by partial splenic embolisation as an alternative to splenectomy and followed up for five years. Results were compared with those in a matched control group of seven patients treated by splenectomy. All patients treated by partial splenic embolisation showed a reduction in blood transfusion requirements comparable with those in the controls and which remained unchanged over the five years. Serious infections that commonly occur in patients splenectomised for thalassaemia did not occur after embolisation, presumably owing to preservation of some immune function by the splenic remnant. By contrast with the change in platelet counts seen after splenectomy, platelet counts remained normal after partial splenic embolisation, so reducing the risk of thromboses. On the other hand, pre-existing leucopenia and thrombocytopenia were corrected after embolisation. It is concluded that partial splenic embolisation provides an alternative to splenectomy for thalassaemia major and is equally effective and much safer.
C Politis; D G Spigos; P Georgiopoulou; H Vrettou; I Economidou; A E Germenis; C Richardson; G Papaevangelou
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British medical journal (Clinical research ed.)     Volume:  294     ISSN:  0267-0623     ISO Abbreviation:  Br Med J (Clin Res Ed)     Publication Date:  1987 Mar 
Date Detail:
Created Date:  1987-06-05     Completed Date:  1987-06-05     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  8302911     Medline TA:  Br Med J (Clin Res Ed)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  665-7     Citation Subset:  AIM; IM    
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MeSH Terms
Embolization, Therapeutic*
Ferritins / blood
Follow-Up Studies
Hypersplenism / etiology,  therapy*
Immunoglobulin A / analysis
Immunoglobulin G / analysis
Leukocyte Count
Platelet Count
Thalassemia / blood,  complications,  therapy*
Reg. No./Substance:
0/Immunoglobulin A; 0/Immunoglobulin G; 9007-73-2/Ferritins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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