| Partial sciatic nerve ligation induced more dramatic increase of neuropeptide Y immunoreactive axonal fibers in the gracile nucleus of middle-aged rats than in young adult rats. | |
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MedLine Citation:
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PMID: 10797555 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neuropeptide changes in primary sensory neurons caused by partial nerve injury are likely involved in the development of neuropathic pain. In this study, using immunocytochemistry, we examined neuropeptide Y (NPY) expression in lumbar dorsal root ganglion (DRG) cells of young adult (2-3 months old) and middle-aged (8-10 months old) rats 4 weeks after partial sciatic nerve ligation (PSNL). Significantly higher NPY immunoreactivity was induced in the injured side DRG neurons, the dorsal horn and the gracile nuclei in middle-aged rats than in young rats. Using combined fluorescent dye tracing and NPY immunostaining, we found in middle-aged rats that 46% injured DRG neurons projected to the gracile nucleus and 45% of injured neurons were also NPY-IR, whereas 42% spared DRG neurons projected to the gracile nucleus and 18% of spared neurons were also NPY-IR. Thus PSNL induces NPY up-regulation in spared as well as injured DRG neurons, both contribute to the increased NPY immunoreactivity in the gracile nucleus in the middle-aged rats. The more dramatic increase of NPY in DRG neurons of middle-aged rats after PSNL shows that the responses to partial nerve injury are age-dependent, that suggests a possible relevance to the higher incidence of neuropathic pain in human middle age. |
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Authors:
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W Ma; M A Bisby |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neuroscience research Volume: 60 ISSN: 0360-4012 ISO Abbreviation: J. Neurosci. Res. Publication Date: 2000 May |
Date Detail:
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Created Date: 2000-06-23 Completed Date: 2000-06-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600111 Medline TA: J Neurosci Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 520-30 Citation Subset: IM |
Copyright Information:
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Copyright 2000 Wiley-Liss, Inc. |
Affiliation:
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Department of Physiology, Faculty of Medicine, Queen's University, Kingston, Ontario, Canada. maweiy@douglas.mcgill.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging* Animals Axonal Transport Axons / metabolism* Fluorescent Dyes / analysis Ganglia, Spinal / cytology, metabolism Immunohistochemistry Ligation Male Medulla Oblongata / cytology, metabolism* Neuropeptide Y / metabolism* Posterior Horn Cells / cytology, metabolism Rats Rats, Sprague-Dawley Sciatic Nerve / injuries*, physiopathology*, surgery |
| Chemical | |
Reg. No./Substance:
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0/Fluorescent Dyes; 0/Neuropeptide Y |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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