| Partial reversal of the iminodipropionitrile-induced hyperkinetic syndrome in rats by alpha-tocopherol (vitamin E). | |
| | |
MedLine Citation:
|
PMID: 3251508 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Rats were treated with the neurotoxin iminodipropionitrile (IDPN), which causes an irreversible movement disorder accompanied by axonal damage similar to that seen in vitamin E deficiency. Animals that received 2 g/kg vitamin E concurrently with 100 mg/kg IDPN for 10 days demonstrated a significantly reduced severity of IDPN-induced dyskinesia (as measured by vertical head movements) compared to animals that received IDPN alone. When animals were treated with 100 mg/kg IDPN for 10 days and then given either 2 g/kg vitamin E or an equivalent volume of sesame oil for 7 days, vitamin E produced a significant reduction in the severity of IDPN-induced dyskinesia. In both experiments, locomotor activity was unchanged by vitamin E. These data suggest a possible involvement of free radical formation in the neurotoxicity of IDPN. |
| | |
Authors:
|
J B Lohr; J L Cadet; R J Wyatt; W J Freed |
Related Documents
:
|
1786288 - Stage-synchronized seminiferous epithelium in rats after manipulation of retinol levels. 9727848 - Thiamine-responsive lactic acidaemia: role of pyruvate dehydrogenase complex. 2865098 - Effects of vitamin e on the distribution and metabolism of nitrofurantoin in rats. 22226488 - Neuroprotection provided by dietary restriction in rats is further enhanced by reducing... 2547578 - Abnormalities in the hypothalamo-pituitary-adrenal axis in spontaneously hypertensive r... 17420618 - Preventive effect of zinc against cadmium-induced oxidative stress in the rat testis. |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
|
Title: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Volume: 1 ISSN: 0893-133X ISO Abbreviation: Neuropsychopharmacology Publication Date: 1988 Dec |
Date Detail:
|
Created Date: 1989-08-04 Completed Date: 1989-08-04 Revised Date: 2011-05-18 |
Medline Journal Info:
|
Nlm Unique ID: 8904907 Medline TA: Neuropsychopharmacology Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 305-9 Citation Subset: IM |
Affiliation:
|
Psychiatry Service, San Diego VA Medical Center, California 92161. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Disease Models, Animal Dyskinesia, Drug-Induced / drug therapy*, physiopathology Male Nitriles / antagonists & inhibitors* Rats Rats, Inbred Strains Vitamin E / therapeutic use* |
| Chemical | |
Reg. No./Substance:
|
0/Nitriles; 111-94-4/3,3'-iminodipropionitrile; 1406-18-4/Vitamin E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Increased daytime sleepiness enhances ethanol's sedative effects.
Next Document: Vocalization accompanying emotional-aversive response induced by carbachol in the cat. Reproducibili...