Document Detail


Partial reversal of carbamazepine-induced water intolerance by demeclocycline.
MedLine Citation:
PMID:  6430315     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The anti-diuretic action of carbamazepine, before and after concurrent treatment with demeclocycline, has been studied in a single epileptic subject, in whom two episodes of status epilepticus had been associated with excessive fluid intake and hyponatraemia. After addition of demeclocyline, free water clearance, plasma arginine vasopressin concentration and serum osmolality (all appreciably reduced after carbamazepine alone) increased but did not revert to normal. The findings are consistent with direct antagonism by demeclocycline of the enhancing effect of carbamazepine on endogenous ADH activity.
Authors:
F W Ballardie; J C Mucklow
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  17     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  1984 Jun 
Date Detail:
Created Date:  1984-09-13     Completed Date:  1984-09-13     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  763-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Carbamazepine / adverse effects*,  antagonists & inhibitors
Demeclocycline / therapeutic use*
Female
Humans
Vasopressins / metabolism
Water Intoxication / chemically induced,  drug therapy*
Chemical
Reg. No./Substance:
11000-17-2/Vasopressins; 127-33-3/Demeclocycline; 298-46-4/Carbamazepine
Comments/Corrections

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