Document Detail

Partial reversal of carbamazepine-induced water intolerance by demeclocycline.
MedLine Citation:
PMID:  6430315     Owner:  NLM     Status:  MEDLINE    
The anti-diuretic action of carbamazepine, before and after concurrent treatment with demeclocycline, has been studied in a single epileptic subject, in whom two episodes of status epilepticus had been associated with excessive fluid intake and hyponatraemia. After addition of demeclocyline, free water clearance, plasma arginine vasopressin concentration and serum osmolality (all appreciably reduced after carbamazepine alone) increased but did not revert to normal. The findings are consistent with direct antagonism by demeclocycline of the enhancing effect of carbamazepine on endogenous ADH activity.
F W Ballardie; J C Mucklow
Related Documents :
3146505 - The effect of cardiopulmonary bypass on plasma protein binding of alfentanil.
7078705 - Phenobarbital therapy in neonatal seizures and the prognostic value of the eeg.
8423885 - Effects of estradiol and progesterone on seizure sensitivity in oophorectomized dba/2j ...
3176115 - Stability of drug concentrations in plasma stored in serum separator blood collection t...
3161825 - Effects of alpha-human atrial natriuretic peptide in essential hypertension.
8900825 - Circannual changes in thyroid hormone physiology: the role of cold environmental temper...
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  17     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  1984 Jun 
Date Detail:
Created Date:  1984-09-13     Completed Date:  1984-09-13     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  763-5     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Carbamazepine / adverse effects*,  antagonists & inhibitors
Demeclocycline / therapeutic use*
Vasopressins / metabolism
Water Intoxication / chemically induced,  drug therapy*
Reg. No./Substance:
11000-17-2/Vasopressins; 127-33-3/Demeclocycline; 298-46-4/Carbamazepine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Differential transplacental binding of valproic acid: influence of free fatty acids.
Next Document:  Effect of valproate on free plasma phenytoin concentrations.