| Partial reversal of carbamazepine-induced water intolerance by demeclocycline. | |
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MedLine Citation:
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PMID: 6430315 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The anti-diuretic action of carbamazepine, before and after concurrent treatment with demeclocycline, has been studied in a single epileptic subject, in whom two episodes of status epilepticus had been associated with excessive fluid intake and hyponatraemia. After addition of demeclocyline, free water clearance, plasma arginine vasopressin concentration and serum osmolality (all appreciably reduced after carbamazepine alone) increased but did not revert to normal. The findings are consistent with direct antagonism by demeclocycline of the enhancing effect of carbamazepine on endogenous ADH activity. |
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Authors:
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F W Ballardie; J C Mucklow |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: British journal of clinical pharmacology Volume: 17 ISSN: 0306-5251 ISO Abbreviation: Br J Clin Pharmacol Publication Date: 1984 Jun |
Date Detail:
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Created Date: 1984-09-13 Completed Date: 1984-09-13 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7503323 Medline TA: Br J Clin Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 763-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Carbamazepine / adverse effects*, antagonists & inhibitors Demeclocycline / therapeutic use* Female Humans Vasopressins / metabolism Water Intoxication / chemically induced, drug therapy* |
| Chemical | |
Reg. No./Substance:
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11000-17-2/Vasopressins; 127-33-3/Demeclocycline; 298-46-4/Carbamazepine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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