|Partial orchiectomy and testis intratubular germ cell neoplasia: World literature review.|
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|PMID: 21976922 Owner: NLM Status: PubMed-not-MEDLINE|
|Approximately 5% of all patients diagnosed with testicular cancer may have contralateral intratubular germ cell neoplasia (ITGCN) and may develop contralateral germ cell tumor. Here, we present a historical review and current literature regarding ITGCN and partial orchiectomy. The PubMed world literature search was performed for articles written in the English language. Search terms used were: Partial orchiectomy and ITGCN, with a return of 322 articles. Articles obtained were from the United States, Germany, Denmark and the Netherlands as well as a few case reports from Australia, France, Turkey and Spain. A critical review of the literature was performed. Partial orchiectomy is an option for the management of testicular malignancy in a select group of patients in whom radical orchiectomy is not desirable, including those with a solitary testicle, bilateral concurrent malignancies and a desire for paternity or being independent from androgen supplementation. Reports have demonstrated the feasibility of partial orchiectomy, but there are strict surgical criteria; tumor less than 2 cm in size, maintenance of cold ischemia, meticulous dissection to maintain testicular blood supply and biopsying of adjacent testicular parenchyma to ensure negative margins and absence of concurrent ITGCN. Partial orchiectomy is followed by testicular irradiation of 18-20 Gy; this radiation dose reduces fertility but maintains leydig cell function with androgen independence. Patients with a history of testicular carcinoma have a 5% chance of developing a metachronous contralateral tumor. Partial orchiectomy is a technically challenging procedure that requires close follow-up, but may represent a reasonable management option in selected patients.|
|Wassim M Bazzi; Omer A Raheem; Sean P Stroup; Christopher J Kane; Ithaar H Derweesh; Tracy M Downs|
|Type: Journal Article|
|Title: Urology annals Volume: 3 ISSN: 0974-7834 ISO Abbreviation: Urol Ann Publication Date: 2011 Sep|
|Created Date: 2011-10-06 Completed Date: 2011-11-10 Revised Date: 2013-05-29|
Medline Journal Info:
|Nlm Unique ID: 101510823 Medline TA: Urol Ann Country: India|
|Languages: eng Pagination: 115-8 Citation Subset: -|
|Department of Surgery, Division of Urology, University of California, San Diego School of Medicine, La Jolla, San Diego, CA, USA.|
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Journal ID (nlm-ta): Urol Ann
Journal ID (publisher-id): UA
Publisher: Medknow Publications, India
© Urology Annals
Received Day: 08 Month: 2 Year: 2011
Accepted Day: 07 Month: 4 Year: 2011
Print publication date: Season: Sep-Dec Year: 2011
Volume: 3 Issue: 3
First Page: 115 Last Page: 118
PubMed Id: 21976922
Publisher Id: UA-3-115
|Partial orchiectomy and testis intratubular germ cell neoplasia: World literature review|
|Wassim M. Bazziaff1|
|Omer A. Raheemaff1|
|Sean P. Stroupaff1|
|Christopher J. Kaneaff1|
|Ithaar H. Derweeshaff1|
|Tracy M. Downs1|
|Department of Surgery, Division of Urology, University of California, San Diego School of Medicine, La Jolla, San Diego, CA, USA
1Department of Urology, University of Wisconsin Public Health, Madison, WI, USA
|Correspondence: Address for correspondence: Dr. Wassim M. Bazzi, Division of Urology, University of California San Diego, 550 15th St. Unit 508, San Diego, CA 92101, USA. E-mail: email@example.com
According to the American Cancer Society statistics, in 2010, approximately 8480 new cases of testicular cancer will be diagnosed and close to 350 men will die of testicular cancer in the United States. Historically, testicular cancer has been associated with either synchronous or metachronous testicular cancer in up to 5% of the cases.[2–5] Even higher rates of concomitant intratubular germ cell neoplasia (ITGCN) or testicular carcinoma in situ (CIS) have been reported. As treatments for retroperitoneal disease have dramatically changed the management landscape in these patients, more and more patients may be found with concerning lesions in their remaining testicle. Patients who undergo bilateral orchiectomies are faced with significant psychologic distress. The increasing prevalence of “at risk” men represents a growing number of testicular cancer patients that may be candidates for testicular-preserving therapies.
Partial orchiectomy aims to preserve some degree of testicular tissue in the setting of a localized testicular cancer. Testicular-preserving strategies have been advocated in particular instances, including the solitary testicle with malignancy in whom paternity or avoidance of exogenous androgen supplementation is desired, in concurrent bilateral testicular malignancies and in those concerned about cosmesis.[7–10] The first reported partial orchiectomy was performed by Richie in the US in 1984. Since then, most of the world literature has been published by groups in Germany, the Netherlands and Denmark, with few case reports of success from Turkey, France and Australia.[12–14] As the incidence of testis cancer increases, a larger group of men may be confronted with this dilemma and may be candidates for testicular-preserving treatments. Here, we present a historical review and current literature regarding partial orchiectomy.
A PubMed (www.pubmed.gov) world literature search was performed for articles written in the English language. Search terms used were partial orchiectomy, with a return of 322 articles. Most of the world literature is from the US, Germany, Denmark and the Netherlands. There are a few case reports from Australia, France, Turkey and Spain. Articles from centers with large experience with CIS of testicle, infertility, bilateral germ cell neoplasia and partial orchiectomy were carefully reviewed.
Weissbach described the details of the inguinal approach for partial orchiectomy. Through an inguinal incision approach, simulating the traditional open orchiectomy inguinal approach, the external oblique fascia is identified and incised with care taken to avoid the ilioinguinal nerve if possible. Next, the spermatic cord is isolated with a Penrose drain. The testicle within the tunica vaginalis is then separated from the scrotal skin by dividing the gubernaculum with care taken to avoid violation of the scrotal skin. Wound towels are placed around the skin incision to protect it from inadvertent tumor exposure, and then the testicle and cord are delivered into the operative field. Intraoperative Doppler and ultrasound can be helpful for planning the excision strategy in order to preserve the vessels and assist with tunical closure. Under cold ischemia, the tunica albuginea is incised and the tumor is isolated and excised. After tumor excision, biopsies of the resection bed are performed [Figure 1] because of the high incidence of surrounding ITGCN (80-90%). After assuring negative tumor margins, the tunica is closed with an absorbable suture and the testicle delivered back to the scrotum.[7, 8] Partial orchiectomy can be a challenging surgical procedure with needed pre- and intraoperative planning to avoid testis vasculature, maintaining cold ischemia and coordinated efforts to biopsy-surrounding areas for ITGCN.
Weissbach and colleagues reported success in their initial series of 10 of 14 patients treated with partial orchiectomy and local radiotherapy. This was followed by the Heidenreich and colleagues series, with no reported local recurrences in 72 of 73 patients after a mean-follow up 91 months.[8–10]
Also known as ITGCN or testicular intraepithelial neoplasia (TIN), it is the precursor of testicular germ cell tumors (GCTs), except for spermatocytic seminomas in elderly men, yolk sac tumors and mature teratomas in infants. ITGCN is non-invasive because the neoplastic cells are confined within the seminiferous tubules. This entity was first described by Skakkebaek in 1972 who, after noticing abnormal spermatogonia pathologic changes on testicular biopsies in two patients who were referred for infertility work-up, was initially unable to characterize these findings but eventually one of the two patients developed embryonal carcinoma in that testicle, the other patient underwent prophylactic orchiectomy with final pathology showing persistent ITGCN. ITGCN is a precursor for GCTs and consists of large, intratubular, gonocyte-like cells with large nuclei and abundant glycogen, having a “fried egg” appearance. ITGCN diagnosis can be further confirmed with placental alkaline phosphatase (PlAP) staining of the testicular biopsy tissue. ITGCN is abundant in tissue surrounding a primary GCT up to 82% of cases after the Heidenreich and colleagues specimen review in their 73 patients’ series.
The incidence of ITGCN varies from 1 to 5% in the reviewed literature.[2, 16] Numerous factors have been associated with an increased incidence of ITGCN; cryptorchidism (2-4%),[17, 18] infertility (2.2%),[3, 18] ambiguous genitalia (25%), contralateral testis in patients with history of testicular cancer (5%) and <1% in the general population, which is similar to the life-time risk of developing testicular carcinoma.[2, 3, 5] The estimated risk of ITGCN progressing to invasive growth is 40, 50 and 70%, with 3, 5 and 7 years, respectively, and the overall progression is 50%.
Radiotherapy for testicular ITGCN was first described in 1986 by Von der Maase and colleagues. After partial orchiectomy, the testicle is typically treated with a 20 Gy dose if one of the adjacent six quadrant biopsies demonstrates ITGCN unless the patient desires paternity.[7, 8] A lower radiation dose can compromise oncologic control and, therefore, most studies have advocated 18-20 Gy, which sustains androgen but not sperm production,[21–23] with few case reports of radiation therapy failure in the literature.[24, 25]
The Dieckmann and colleagues review of 1954 patients with a unilateral GCT who underwent a contralateral testicular biopsy concurrently showed a prevalence of 4.9%, with testicular atrophy having a 4.3-fold increased risk of having contralateral ITGCN. Patients with ITGCN were significantly younger, and only three patients with negative ITGCN on biopsying went on to develop frank carcinoma. Because of similar incidence rates, their data suggest that ITGCN can be a precursor for testicular carcinoma.
Contralateral testicular biopsying is performed in Europe, with data showing a concomitant contralateral ITGCN rate of 4-6%, a false-negative biopsying rate close to 0.5% and a decrease in the needed follow-up length from 25 years to 5 years after negative biopsying. Von der Maase and colleagues estimated the risk of developing invasive growth after ITGCN to be 40% within 3 years and 50% within 5 years. None of their biopsied 473 patients without ITGCN developed contralateral testicular cancer after 12-96 months follow-up and no serious complications arose from their biopsies.
Biopsying the contralateral testicle to look for ITGCN is not practiced in the US. Herr and colleagues did not recommend routine biopsying because of the low incidence of contralateral ITGCN and the emotional distress on a patient with a positive finding. Another argument against routine biopsying is the markedly improved survival since the introduction of platinum-based chemotherapy. Their consensus in the literature on biopsying high-risk patients; prior infertility, cryptorchidism and atrophic testicle-sentence is unclear. The European germ cell cancer consensus group (EGCCCG) has outlined specific characteristics of high-risk patients who might be considered for contralateral testis biopsy; testicular volume <12 ml, history of cryptorchidism or age <30 years.[30–31] This approach allows intervention, generally with radiation, before an invasive tumor is evident thus sparing the testis.
The reviewed literature shows that most bilateral testicular GCTs are seminomas and occur metachronously on an average after 4 years.[32, 33] In the Klatte and colleagues review, bilateral tumors are of similar histologies in more than 50% of the cases, and 74% were seminomas. More important is the observation that having a history of testicular GCT increases the risk of having a contralateral tumor by 26-fold.
The Memorial Sloan-Kettering Cancer Center (MSKCC) reported an overall incidence of bilateral testicular cancer of 1.5% in a review of patients spanning 50 years and a decrease in the incidence of contralateral cancer with time. This is consistent with the hypothesis that treatment with cisplatin chemotherapy decreased the risk of developing a contralateral testicular tumor. Similar findings in the Sonneveld and colleagues review showed that the overall prevalence of bilateral testicular cancer in stage I patients was 3.6%, and has slightly decreased over the past three decades, attributed to intensive follow-up, improvement of radiodiagnostic techniques, serum tumor markers and patient education, which have resulted in earlier lower-stage diagnosis of contralateral tumors and hence improved prognosis.
Whether cisplatin-based chemotherapy may eradicate testicular ITGCN is a matter of debate in the reviewed literature. Kleinschmidt and colleagues recently investigated the eradication of ITGCN after receiving carboplatin or a combination of platinum, etoposide and bleomycin (PEB). Overall, seven of 11 patients failed either of these chemotherapeutic regimens after undergoing biopsying at a mean of 8.8 months post-treatment. Reasons that may keep platinum-based chemotherapies from completely eradicating ITGCN include the blood-testes barrier and the possibility that ITGCN is resistant to chemotherapies, with increasing success for the treatment of initial testicular carcinoma and all reports recommending close follow-up for contralateral tumor occurrence.
On the other hand, some reports have attributed the decreased incidence of contralateral testicular tumors to platinum-based chemotherapy.[29, 33] Van Basten and colleagues, in their review of testicular cancer in Dutch men, noted that a three-times lower incidence rate of a contralateral testicular tumor was found in the chemotherapy subgroup compared with those on surveillance. Fossa and colleagues in their review of the surveillance, epidemiology and end results database (SEER) showed a decreased incidence of contralateral testicular cancer that they hypothesized could be related to platinum-based chemotherapy.
Partial orchiectomy for testicular carcinoma is more commonly practiced in Europe than in the US. It is suitable for patients with a solitary testicle who seek paternity and for those who seek independence from androgen supplementation. For the patient to be a candidate for partial orchiectomy, the recommended tumor size is less than 2 cm, tumor location needs to be far from the testicular vasculature and the protocol described by Weissbach includes six biopsies of tumor surroundings to rule out residual ITGCN. Because of the high concurrence of ITGCN (80-90%), those patients will be referred for radiotherapy, and the recommended dose is 18-20 Gy. Because of the excellent response of testicular GCTs to platinum-based chemotherapy, patients’ will continue to live longer and will need to be routinely followed-up with physical examination and/or imaging of the contralateral testicle.
Source of Support: Nil
Conflict of Interest: None.
|1.||Jemal A,Siegel R,Xu J,Ward E. Cancer statistics, 2010CA Cancer J ClinYear: 20106027730020610543|
|2.||Dieckmann KP,Skakkebaek NE. CIS of the testis: Review of biological and clinical featuresInt J CancerYear: 1999838152210597201|
|3.||Møller H,Skakkebaek NE. Risk of testicular cancer in Subfertile men: Case–control studyBMJYear: 19993185596210037628|
|4.||Dieckmann K,Boeckmann W,Brosig W,Jonas D,Bauer HW. Bilateral Testicular Germ Cell Tumors: Report of nine cases and Review of the literatureCancerYear: 198657125483002601|
|5.||Harland SJ,Cook PA,Fossa SD,Horwich A,Mead GM,Parkinson MC,et al. Intratubular germ cell neoplasia of the contralateral testis in testicular cancer: Defining ahigh risk groupJ UrolYear: 1998160135379751353|
|6.||Heidenreich A,Hofmann R. Quality of life issues in the treatment of testicular cancerWorld J UrolYear: 199917230810460406|
|7.||Weissbach L. Organ Preserving Surgery of Malignant Germ Cell TumorsJ UrolYear: 19951539037966800|
|8.||Heidenreich A,Bonfig R,Derschum W,Von Vietsch H,Wilbert D. A conservative approach to bilateral testicular germ cell tumorsJ UrolYear: 19951531037966739|
|9.||Heidenreich A,Holtl W,Albrecht W,Pont J,Engelmann UH. Testis-preserving surgery in bilateral testicular germ cell tumorsBr J UrolYear: 19977925379052478|
|10.||Heidenreich A,Weibbach L,Holtl W,Albers P,Kliesch S,Kohrmann K,et al. Organ Sparing Surgery for Malignant Germ Cell Tumor of the TestisJ UrolYear: 20011662161511696727|
|11.||Richie JP. Simultaneous bilateral testis tumors with unorthodox managementWorld J UrolYear: 1984274|
|12.||Kirkali Z,Tuzel E,Canda AE,Mungan MU. Testis sparing surgery for the treatment of a sequential bilateral testicular germ cell tumorInt J UrolYear: 20018710211851774|
|13.||Houlgatte A,De La Taille A,Fournier R,Goluboff ET,Camporo P,Houdelette P. Paternity in a patient with seminoma and carcinoma in situ in a solitary testis treated by partial orchidectomyBJU IntYear: 199984374510468744|
|14.||Hughes P. Partial Orchidectomy for Malignancy with Consideration of carcinoma in situANZ J SurgYear: 20067692416483305|
|15.||Skakkebaek N. Possible Carcinoma-in-situ of the TestisLancetYear: 1972251674115573|
|16.||Sonneveld DJ,Schraffordt Koops S,Sleijfer D,Hoekstra HJ. Bilateral Testicular Germ Cell Tumours in Patients with Initial Stage I Disease: Prevalence and Prognosis - A Single Centre's 30 Years’ ExperienceEur J CancerYear: 199834136379849418|
|17.||Dieckmann KP,Pichlmeier U. Clinical epidemiology of testicular germ cell tumorsWorld J UrolYear: 20042221415034740|
|18.||Giwercman A,Bruun E,Frimodt-Moller C,Skakkebaek NE. Prevalence of carcinoma in situ and other histopathological abnormalities in testes of men with a history of cryptorchidismJ UrolYear: 198914299810012571738|
|19.||Von Der Maase H,Rorth M,Walbom-Jorgensen S,Sorensen B,Christophersen IS,Hald T,et al. Carcinoma in situ of contralateral testis in patients with testicular germ cell cancer: Study of 27 cases in 500 patientsBr Med J (Clin Res Ed)Year: 19862931398401|
|20.||Lee E,Holzbeierlein J. Management of the contralateral testicle in patients with unilateral testicular cancerWorld J UrolYear: 200927421619373474|
|21.||Von der Maase H,Giwercman A,Skakkebaek NE. Radiation treatment of carcinoma-in-situ of testisLancetYear: 1986162452869338|
|22.||Giwercman A,Von Der Maase H,Berthelsen JG,Rorth M,Bertelsen A,Skakkebaek NE. Localized Irradiation of Testes with CIS: Effects on Leydig Cell Function and Eradication of Malignant Germ Cells in 20 PatientsJ Clin Endocrinol MetabYear: 1991735966031908483|
|23.||Petersen P,Giwercman A,Daugaard G,Rorth M,Petersen J,Skakkebaek N,et al. Effect of Graded Testicular Doses of Radiotherapy in Patients Treated for Carcinoma-in-situ in the TestisJ Clin OncolYear: 20022015374311896102|
|24.||Dieckmann KP,Lauke H,Michl U,Winter E,Loy V. Testicular Germ Cell Cancer despite Previous Local Radiotherapy to the TestisEur UrolYear: 2002416435012074782|
|25.||Dotsch M,Brauers A,Buttner R,Nolte-Ernsting C,Eble M,Jakse G. Malignant Germ Cell Tumor of the Contralateral Testis after Radiotherapy for Testicular Intraepithelial NeoplasiaJ UrolYear: 2000164452310893614|
|26.||Dieckmann KP,Loy V. Prevalence of Contralateral Testicular Intraepithelial Neoplasia in Patients with Testicular Germ Cell NeoplasmsJ Clin OncolYear: 1996143126328955658|
|27.||Dieckmann KP,Loy V. False-negative biopsies for the diagnosis of testicular intraepithelial neoplasia (TIN) - an updateEur UrolYear: 2003435162112705996|
|28.||Herr HW,Sheinfeld J. Is Biopsy of the Contralateral Testis Necessary in Patients with Germ Cell Tumors?J UrolYear: 1997158133149302113|
|29.||Fossa SD,Chen J,Schonfeld SJ,McGlynn KA,McMaster ML,Gail MH,et al. Risk of Contralateral Testicular Cancer: A Population-based study of 29,515 U.S. MenJ Natl Cancer InstYear: 20059710566616030303|
|30.||Krege S,Beyer J,Souchon R,Albers P,Albrecht W,Algaba F,et al. European consensus conference on diagnosis and treatment of germ cell cancer: A report of the second meeting of the European Germ Cell Cancer Consensus group (EGCCCG): Part IEur UrolYear: 2008534789618191324|
|31.||Montie JE. Carcinoma in situ of the testis and bilateral carcinomaUrol Clin North AmYear: 199320127328434432|
|32.||Klatte T,De Martino M,Arensmeier K,Reiher F,Allhoff E,Klatte D. Management and outcome of bilateral testicular germ cell tumors: A 25-year single center experienceInt J UrolYear: 200815821618657202|
|33.||Holzbeierlein J,Sogani P,Sheinfeld J. Histology and Clinical Outcomes in patients with Bilateral Testicular Germ Cell Tumors: The Memorial Sloan Kettering Cancer Center Experience 1950 to 2001J UrolYear: 20031692122512771732|
|34.||Kleinschmidt K,Dieckmann KP,Georgiew A,Loy V,Weissbach L. Chemotherapy is of Limited Efficacy in the Control of Contralateral Testicular Intraepithelial Neoplasia in Patients with Testicular Germ Cell CancerOncologyYear: 20097733919440001|
|35.||Van Basten JP,Hoekstra HJ,Van Driel MF,Sleijfer DT,Droste JH,Schraffordt Koops H. Cisplatin-Based Chemotherapy Changes the Incidence of Bilateral Testicular CancerAnn Surg OncolYear: 1997434289181235|
[Figure ID: F1]
Biopsying scheme after tumor enucleation (T = tumor, numbers represent tri-planar biopsies)
Keywords: Intratubular germ cell neoplasia, partial orchiectomy, testicular carcinoma in situ.
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