Document Detail

Partial off-loading of longitudinal tension induces arterial tortuosity.
MedLine Citation:
PMID:  15746437     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Arterial tortuosity is a frequent manifestation of vascular disease and collateral vessel growth, but its causes are poorly understood. This study was designed to assess the relationship between the development of tortuosity and the mechanical forces that are imposed on arterial tissue. METHODS AND RESULTS: Axial strain in rabbit carotid arteries was reduced from 62+/-2% to 33+/-2% by implanting an interposition graft, prepared from the contralateral carotid, at the downstream end of the artery. Axial strain remained unchanged for 12 weeks; however, all vessels became tortuous because of tissue growth and remodeling. After 7 days, there was a marked elevation in proliferation rates of endothelial and smooth muscle cells; however, increased apoptosis was also detected, and no net accumulation of DNA was observed. Significant accumulations of elastin (24%) and total collagen (26%) occurred by 5 weeks. Gelatin zymography detected upregulation and activation of matrix metalloproteinase-2 (MMP-2), and confocal microscopy revealed enlargement of fenestrae in the internal elastic lamina. MMP inhibition by treatment with doxycycline prevented enlargement of fenestrae and development of tortuosity, and it enabled normalization of axial strain by 5 weeks. CONCLUSIONS: These findings indicate that substantial axial strain is necessary to sustain the morphological stability of arteries, and that a reduction in strain results in arterial tortuosity attributable to aberrant MMP activity.
Zane S Jackson; Dorota Dajnowiec; Avrum I Gotlieb; B Lowell Langille
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-03-03
Journal Detail:
Title:  Arteriosclerosis, thrombosis, and vascular biology     Volume:  25     ISSN:  1524-4636     ISO Abbreviation:  Arterioscler. Thromb. Vasc. Biol.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-05-02     Completed Date:  2005-12-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9505803     Medline TA:  Arterioscler Thromb Vasc Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  957-62     Citation Subset:  IM    
Department of Laboratory Medicine and Pathobiology, University of Toronto and Toronto General Research Institute, University Health Network, Ontario, Canada.
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MeSH Terms
Apoptosis / physiology
Carotid Arteries / pathology*,  physiopathology*,  transplantation
Carotid Artery Diseases / pathology*,  physiopathology*
Cell Division / physiology
Collagen / metabolism
Elastin / metabolism
Endothelium, Vascular / metabolism,  pathology,  physiopathology
Matrix Metalloproteinase 2 / metabolism
Muscle, Smooth, Vascular / metabolism,  pathology,  physiopathology
Stress, Mechanical
Tensile Strength / physiology*
Transplantation, Autologous
Weight-Bearing / physiology
Reg. No./Substance:
9007-34-5/Collagen; 9007-58-3/Elastin; EC Metalloproteinase 2
Comment In:
Arterioscler Thromb Vasc Biol. 2005 May;25(5):892-4   [PMID:  15863721 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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