Document Detail

Partial motor restoration upon administration of sildenafil: a case study.
MedLine Citation:
PMID:  22256833     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Extensive research in the past decade has confirmed that the adult brain maintains some plasticity, including neural cell birth, migration and integration. Pre-clinical data strongly suggest that phosphodiesterase type 5 (PDE5) inhibitors promote cerebral neovascularization and neurogenesis. Animal studies of cerebral stroke suggest potential regenerative benefits following treatment with sildenafil citrate, a PDE5 inhibitor. This study reports a case in which compassionate use of sildenafil was investigated as a treatment to improve physical functioning, more than 4 decades after development of spastic quadriplegia during the 1st-2nd year of life.
METHODS: Sildenafil 100 mg was administered every 24 hours for 7 months.
RESULTS: Sildenafil treatment was associated with clinical (functional) improvement.
CONCLUSIONS: The activity of sildenafil on cerebral neovascularization and neurogenesis may be the mechanism for the observed functional benefits.
Antonio Cocchiarella
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Developmental neurorehabilitation     Volume:  15     ISSN:  1751-8431     ISO Abbreviation:  Dev Neurorehabil     Publication Date:  2012  
Date Detail:
Created Date:  2012-01-19     Completed Date:  2012-05-17     Revised Date:  2012-06-18    
Medline Journal Info:
Nlm Unique ID:  101304394     Medline TA:  Dev Neurorehabil     Country:  England    
Other Details:
Languages:  eng     Pagination:  39-43     Citation Subset:  IM    
Clinical Rehabilitation Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA.
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MeSH Terms
Brain / blood supply
Cerebrovascular Circulation / drug effects*
Compassionate Use Trials
Disabled Persons / rehabilitation*
Motor Skills / drug effects*
Muscle Strength / drug effects
Neural Conduction / drug effects
Neurogenesis / drug effects*,  physiology
Neuronal Plasticity
Phosphodiesterase 5 Inhibitors / administration & dosage,  pharmacology*,  therapeutic use*
Piperazines / administration & dosage,  pharmacology*,  therapeutic use*
Purines / administration & dosage,  pharmacology,  therapeutic use
Quadriplegia / rehabilitation*
Sulfones / administration & dosage,  pharmacology*,  therapeutic use*
Reg. No./Substance:
0/Phosphodiesterase 5 Inhibitors; 0/Piperazines; 0/Purines; 0/Sulfones; 139755-83-2/sildenafil

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