| Partial mechanical long-term support with the CircuLite Synergy pump as bridge-to-transplant in congestive heart failure. | |
| | |
MedLine Citation:
|
PMID: 20101535 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Full mechanical support with a left ventricular assist device (LVAD) is often limited to very sick patients, as the only survival option. This European multicenter study analyzes the effect of partial mechanical support as bridge-to-transplant in a less sick heart failure patient group. METHODS: The CircuLite Synergy device is implanted via a small right-sided thoracotomy with an inflow cannula in the left atrium and an outflow graft connected to the right subclavian artery without the use of extracorporeal circulation. The pump itself sits in a "pacemaker" pocket subcutaneously in the right clavicular groove. It is able to pump up to 3.0 l/min and partially unload the left ventricle. RESULTS: The device was implanted in 25 patients on the cardiac transplant waiting list (20 males), aged 55.5 +/- 9.6 yrs with an ejection fraction of 21.6 +/- 6.0 %, a mean arterial pressure of 73.5 +/- 8.5 mmHg, a pulmonary capillary wedge pressure of 27.2 +/- 7.8 mmHg and cardiac index of 1.9 +/- 0.4 l/min/m (2). Duration of support ranged from 6 to 238 days. Right heart catheterization showed significant hemodynamic improvement in the short- and intermediate-term after implantation with increases in arterial pressure from 72.6 +/- 11.0 to 79.4 +/- 8.6 mmHg ( P = 0.04) and in cardiac index from 2.0 +/- 0.4 to 2.7 +/- 0.6 l/min/m (2) ( P = 0.003) with a reduction in pulmonary capillary wedge pressure from 28.5 +/- 6.0 to 19.7 +/- 6.9 mmHg ( P = 0.012). CONCLUSIONS: The CircuLite Synergy device is a partial support pump, which is easy to implant and which provides hemodynamic benefits in bridging heart failure patients to cardiac transplant. |
| | |
Authors:
|
S Klotz; B Meyns; A Simon; T Wittwer; P Rahmanian; C Schlensak; T T D T Tjan; H H Scheld; D Burkhoff |
Related Documents
:
|
9039025 - Role of extra- and intracellular ca2+ in the lymphatic myogenic response. 18812745 - The capability of trapping gaseous microemboli of two pediatric arterial filters with p... 11872015 - The seventh prototype of the mini-spindle-pump: does it fulfill the expectations of a s... 11569795 - Microchip injection and separation anomalies due to pressure effects. 19917875 - Sex differences in pulse pressure trends with age are cross-cultural. 22209265 - Hepatic venous pressure measurements: comparison of end-hole and balloon catheter methods. |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Multicenter Study Date: 2010-01-25 |
Journal Detail:
|
Title: The Thoracic and cardiovascular surgeon Volume: 58 Suppl 2 ISSN: 1439-1902 ISO Abbreviation: Thorac Cardiovasc Surg Publication Date: 2010 Feb |
Date Detail:
|
Created Date: 2010-01-26 Completed Date: 2010-05-27 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7903387 Medline TA: Thorac Cardiovasc Surg Country: Germany |
Other Details:
|
Languages: eng Pagination: S173-8 Citation Subset: IM |
Copyright Information:
|
(c) Georg Thieme Verlag KG Stuttgart-New York. |
Affiliation:
|
Department of Thoracic and Cardiovascular Surgery, University Hospital of Muenster, Albert-Schweitzer-Strasse 33, Muenster, Germany. Stefan.Klotz@ukmuenster.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Female Heart Failure / surgery, therapy* Heart Transplantation Heart-Assist Devices* Humans Male Middle Aged Time Factors Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Drug treatment for chronic systolic heart failure.
Next Document: Considerations for patients awaiting heart transplantation.