Document Detail

Partial liquid ventilation combined with two different gas ventilatory strategies in acute lung injury in piglets: Effects on gas exchange, respiratory mechanics, and hemodynamics.
MedLine Citation:
PMID:  12677559     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/PURPOSE: Partial liquid ventilation (PLV) has been shown to improve oxygenation and lung mechanics in different models of acute lung injury. This study was designed to investigate the effects of 2 gas ventilatory strategies during PLV on gas exchange, respiratory mechanics, and hemodynamics in acute lung injury in piglets. METHODS: After induction of acute lung injury, the animals were assigned randomly to 2 groups with different positive end-expiratory pressure (PEEP) levels and tidal volumes (Vt) (group A, Vt > 12.5 mL/kg; PEEP = 6 cm H2O, n = 7; group B, Vt < 9 mL/kg, PEEP = 12 cm H2O, n = 7). Thereafter, the perfluorocarbon (PFC) liquid (30 mL/kg) was instilled into the endotracheal tube. Cardiorespiratory parameters were measured at baseline, after induction of acute lung injury, and every 30 minutes up to 120 minutes. RESULTS: During PLV, oxygenation significantly improved with no difference between both gas ventilatory strategies. The high PEEP-moderate Vt gas ventilatory strategy reduced the inspiratory airway resistance and was associated with moderate hypercapnia. There were no significant differences in hemodynamics and respiratory compliance between both gas ventilatory strategies. CONCLUSIONS: The results of this pilot study suggest that oxygenation was equally improved during PLV. This effect was independent of the mode of gas ventilation. However, the high PEEP-moderate Vt gas ventilatory technique resulted in moderate hypercapnia.
Gerfried Zobel; Siegfried Rödl; Berndt Urlesberger; Igor Knez; Drago Dacar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric surgery     Volume:  38     ISSN:  1531-5037     ISO Abbreviation:  J. Pediatr. Surg.     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-04-04     Completed Date:  2003-11-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0052631     Medline TA:  J Pediatr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  527-33     Citation Subset:  IM    
Copyright Information:
Copyright 2003, Elsevier Science (USA). All rights reserved.
Department of Pediatrics, University of Graz, Austria.
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MeSH Terms
Acute Disease
Carbon Dioxide / blood
Disease Models, Animal
Infant, Newborn
Irrigation / adverse effects
Liquid Ventilation*
Oleic Acid / toxicity
Oxygen / blood
Partial Pressure
Pilot Projects
Positive-Pressure Respiration / methods*
Pulmonary Gas Exchange*
Respiratory Distress Syndrome, Newborn
Respiratory Insufficiency / chemically induced,  physiopathology,  therapy
Respiratory Mechanics*
Tidal Volume
Reg. No./Substance:
112-80-1/Oleic Acid; 124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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