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Partial lipectomy reduces dimethylhydrazine-induced carcinogenic initiation in the colon of rats.
MedLine Citation:
PMID:  24299902     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
This study investigated whether visceral adipose tissue directly modulates the development of preneoplastic lesions in the colon of carcinogen-treated rats. Wistar rats (n=64) were randomly assigned to 8 experimental groups in two experiments. In one experiment, 32 rats were exposed or not to either carcinogen treatment (dimethylhydrazine, DMH; 125mg/kg) or high-fat diet (standard chow enriched with 14% lard) or both for 56 days. In a second experiment, 32 rats were exposed to a carcinogen or they underwent partial lipectomy or both for 30 days (partial lipectomy groups underwent ablation of mesenteric and parametrial fat pads, whereas sham groups did not; all rats were fed with standard chow). Colon was collected for histopathological analysis. After 56 experimental days a high-fat diet increased carcinogenic mutations in the colonic epithelia. Partial lipectomy reduced weight gain in carcinogen-exposed rats and decreased the de novo formation of mesenteric and parametrial fat pads. Partial lipectomy significantly inhibited the mutational process after 30 days: there were fewer colonic preneoplastic lesions and less proliferation, apoptosis, and inflammation. These data suggest that visceral adipose tissue promotes colon carcinogenesis and enhances the establishment and expansion of genetically mutated cells in colonic epithelia.
Authors:
Vinicius Kannen; Mauro César Silveira Moreira; Ana Maria Waaga-Gasser; Patricia Modiano; Jorge Elias Junior; Cleverson R Fernandes; Sérgio B Garcia
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-11-30
Journal Detail:
Title:  Toxicology     Volume:  -     ISSN:  1879-3185     ISO Abbreviation:  Toxicology     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-12-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0361055     Medline TA:  Toxicology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013. Published by Elsevier Ireland Ltd.
Affiliation:
Department of Surgery I, Molecular Oncology and Immunology, University of Wuerzburg,Germany. Electronic address: vinicius.cardoso@uni-wuerzburg.de.
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