Document Detail

Partial laryngectomy after irradiation failure.
MedLine Citation:
PMID:  2006814     Owner:  NLM     Status:  MEDLINE    
Forty-three patients who had partial laryngectomies after radiotherapy were evaluated. Forty-two had failed irradiation for laryngeal carcinoma. Nine had supraglottic procedures, 3 endoscopic, and 31 vertical partial. Twelve (28%) required subsequent completion laryngectomy. Major complications included laryngeal stenosis in 1, incompetent laryngeal sphincters in 2, mucocutaneous fistulas in 3, and delayed deglutition in 3. Six patients had positive permanent section margins. In 5 of those, intraoperative frozen sections had been taken and were negative. Recurrent or persistent disease was eventually demonstrated in all patients with positive margins. The 2-year determinant disease-free survival rate for stage I and II disease was 85%. Three-year disease-free survival was 50% for stage III and IV disease. Partial laryngectomies, including supraglottic, can be done after irradiation failure with a high expectation of cure and acceptable morbidity. Immediate additional operation should be considered in patients with positive margins.
R D Nichols; S A Mickelson
Related Documents :
12074084 - Combined endoscopic laser and radiotherapy palliation of advanced rectal cancer.
7401854 - Laryngeal radiation after hemilaryngectomy.
11223824 - Pulmonary metastasectomy: might the type of resection affect survival?
12499094 - Bronchoscopic treatment of patients with intraluminal microinvasive radiographically oc...
12453334 - Phase i radioimmunotherapy trial with iodine-131--labeled humanized mn-14 anti-carcinoe...
21173374 - Factors predicting outcome in malignant minor salivary gland tumors of the oropharynx.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Annals of otology, rhinology, and laryngology     Volume:  100     ISSN:  0003-4894     ISO Abbreviation:  Ann. Otol. Rhinol. Laryngol.     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-04-24     Completed Date:  1991-04-24     Revised Date:  2006-05-15    
Medline Journal Info:
Nlm Unique ID:  0407300     Medline TA:  Ann Otol Rhinol Laryngol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  176-80     Citation Subset:  AIM; IM    
Department of Otolaryngology, Henry Ford Hospital, Detroit, Michigan 48202.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Combined Modality Therapy
Follow-Up Studies
Laryngeal Neoplasms / mortality,  pathology,  therapy*
Laryngectomy* / adverse effects,  methods
Middle Aged
Neoplasm Recurrence, Local / surgery
Neoplasm Staging
Radiotherapy Dosage
Survival Rate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Histologic evaluation of the larynx in sudden infant death syndrome.
Next Document:  Cholesterol cysts of the temporal bone: diagnosis and treatment.