Document Detail

Partial food restriction increases hepatic inner ring deiodinating activity in the chicken and the rat.
MedLine Citation:
PMID:  8775060     Owner:  NLM     Status:  MEDLINE    
The effects of a long term partial food restriction were studied in chickens and rats. In chickens the treatment resulted in increased plasma T4 levels while T4 levels in rats remained unchanged. Plasma T3 decreased in both species. In vitro hepatic outer ring deiodinating type I (ORD-I) activity was not influenced by the food restriction, suggesting that the amount of ORD-I enzyme present in the liver remained unchanged. In vitro hepatic inner ring deiodinating type III activity, on the contrary, was greatly increased in both species. This increase may contribute to the decreased circulating T3 levels by increasing the degradation of T3 and diverting the deiodination of T4 to rT3 instead of to T3.
V M Darras; M Cokelaere; E Dewil; S Arnouts; E Decuypere; E R Kühn
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  General and comparative endocrinology     Volume:  100     ISSN:  0016-6480     ISO Abbreviation:  Gen. Comp. Endocrinol.     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-12-03     Completed Date:  1996-12-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370735     Medline TA:  Gen Comp Endocrinol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  334-8     Citation Subset:  IM    
Laboratory of Comparative Endocrinology, Zoological Institute, KULeuven, Belgium.
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MeSH Terms
Body Weight
Diet / adverse effects*
Liver / metabolism*
Rats, Wistar
Thyroid Hormones / blood*
Reg. No./Substance:
0/Thyroid Hormones

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