Document Detail

Partial extracorporeal carbon dioxide removal using a standard continuous renal replacement therapy device: a preliminary study.
MedLine Citation:
PMID:  25000386     Owner:  NLM     Status:  Publisher    
To test the feasibility, safety, and efficacy of partial extracorporeal CO2 removal (PECCO2R) using a standard continuous renal replacement (CRRT) device with a paediatric oxygenation membrane introduced into the circuit in a serial manner. In this retrospective single-centre study we have studied mechanically ventilated patients with persistent significant respiratory acidosis and acute renal failure requiring ongoing CRRT. Sixteen patients were treated with our PECCO2R device. PaCO2 and arterial pH were measured before as well as at six and twelve hours after PECCO2R implementation. Hemodynamic parameters were continuously monitored. Our PECCO2R system was efficient to significantly reduce PaCO2 and increase arterial pH. The median PaCO2 before treatment was 77 mmHg (59-112) with a median reduction of 24 mmHg after six hours and 30 mmHg after twelve hours (31% and 39 %, respectively). The median pH increase was 0.16 at six hours and 0.23 at twelve hours. PECCO2R treatment had no effect on oxygenation. No complication was observed. Our PECCO2R approach based on the simple introduction of a paediatric ECMO membrane into the circuit of a standard CRRT device is easy to implement, safe and efficient to improve respiratory acidosis.
Quintard Jean-Marie; Barbot Olivier; Thevenot Florence; de Matteis Olivier; Benayoun Laurent; Leibinger Frank
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-7-3
Journal Detail:
Title:  ASAIO journal (American Society for Artificial Internal Organs : 1992)     Volume:  -     ISSN:  1538-943X     ISO Abbreviation:  ASAIO J.     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-7-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204109     Medline TA:  ASAIO J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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