Document Detail

Partial blastema formation after amputation in adult mice.
MedLine Citation:
PMID:  7411075     Owner:  NLM     Status:  MEDLINE    
The amputation surface of toes of adult mice was treated by repeated skin removal and exposure to a saturated solution of NaCl. Histological examination of treated appendages revealed the presence of wound epithelium, numerous irregularly oriented subepithelial cells, many of which were mitotically active as indicated by [3H] thymidine uptake, and a remodeled viable bone adjacent to subepithelial cells. Thus, tissues at the amputation site of mammals can resemble comparable tissues of newt limb stumps at an early stage of regeneration. Complete blastema formation was not achieved, however.
D A Neufeld
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of experimental zoology     Volume:  212     ISSN:  0022-104X     ISO Abbreviation:  J. Exp. Zool.     Publication Date:  1980 Apr 
Date Detail:
Created Date:  1980-11-20     Completed Date:  1980-11-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375365     Medline TA:  J Exp Zool     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  31-6     Citation Subset:  IM    
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MeSH Terms
Bone Regeneration
DNA / biosynthesis
Sodium Chloride / therapeutic use
Toes / surgery
Wound Healing / drug effects*
Reg. No./Substance:
7647-14-5/Sodium Chloride; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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