Document Detail

Partial Na+ dependence of DL-2-hydroxy-4-(methylthio)butanoic acid uptake in the chicken small intestine.
MedLine Citation:
PMID:  18577621     Owner:  NLM     Status:  MEDLINE    
Methionine hydroxy analogue DL-2-hydroxy-(4-methylthio)butanoic acid (HMTBA) is commonly used as a supplemental source of Met in commercial animal diets. To better understand the uptake of this analogue by the chicken intestine, the aim of the present study was to assess the contribution of Na+ gradient on HMTBA accumulation in everted sacs of the chicken small intestine (duodenum, jejunum, and ileum). In the presence of an H+ gradient, uptake was lower in the absence of Na+ along the chicken small intestine, although no significant differences were detected in the duodenum. In contrast, in the absence of an H+ gradient, no significant differences were detected between the 2 Na+ conditions. In conclusion, the observed relationship between Na+ and H+ dependence indicates the participation of the apical Na+/H+ exchanger in HMTBA uptake in the chicken small intestine.
R Martín-Venegas; P A Geraert; R Ferrer
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Poultry science     Volume:  87     ISSN:  0032-5791     ISO Abbreviation:  Poult. Sci.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-25     Completed Date:  2008-10-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401150     Medline TA:  Poult Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1392-4     Citation Subset:  IM    
Departament de Fisiologia, Facultat de Farmàcia, Universitat de Barcelona, Barcelona, Spain.
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MeSH Terms
Biological Transport, Active / physiology*
Chickens / metabolism*
Intestine, Small / metabolism*
Methionine / analogs & derivatives*,  pharmacokinetics
Organ Culture Techniques
Sodium / pharmacology*
Reg. No./Substance:
583-91-5/alpha-hydroxy-gamma-methylmercaptobutyric acid; 63-68-3/Methionine; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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