Document Detail

Partial HELLP syndrome in pregnancy complicated by recurrent deep vein thromboses and palmar skin lesions in a patient with prothrombin gene 20210a mutation and antiphospholipid antibodies: an unusual case.
MedLine Citation:
PMID:  17610004     Owner:  NLM     Status:  MEDLINE    
A patient who developed thrombocytopenia and hypertension accompanied by high levels of antiphospholipid antibodies and abnormal liver function tests in the absence of a hemolytic anemia necessitating termination of pregnancy developed bilateral lower limb thromboses accompanied by painful maculo papular lesions on the palms of both hands a few days after ending the pregnancy. She was then also found to have a prothrombin gene G20210A mutation. She was treated with anticoagulation therapy, but her postpartum course was further complicated by pulmonary embolus. A Greenfield filter was inserted into the inferior vena cava. On low molecular weight heparin, her next pregnancy was uneventful and without any complications.
Ronald A Asherson; Cathy Spargo; Jose A Gómez-Puerta
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2007-07-03
Journal Detail:
Title:  Clinical rheumatology     Volume:  27     ISSN:  0770-3198     ISO Abbreviation:  Clin. Rheumatol.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-03-04     Completed Date:  2008-05-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211469     Medline TA:  Clin Rheumatol     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  245-8     Citation Subset:  IM    
Division of Immunology, School of Pathology, University of the Witwatersrand School of Medicine, Johannesburg, South Africa.
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MeSH Terms
Abortion, Therapeutic
Antibodies, Antiphospholipid*
Anticoagulants / therapeutic use
HELLP Syndrome*
Heparin, Low-Molecular-Weight / therapeutic use
Prothrombin / genetics*
Pulmonary Embolism / drug therapy,  etiology*
Venous Thrombosis / drug therapy
Reg. No./Substance:
0/Antibodies, Antiphospholipid; 0/Anticoagulants; 0/Heparin, Low-Molecular-Weight; 9001-26-7/Prothrombin

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