| The partial coherence method for assessment of impaired cerebral autoregulation using near-infrared spectroscopy: potential and limitations. | |
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MedLine Citation:
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PMID: 20204795 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The most important forms of brain injury in premature infants are partly caused by disturbances in cerebral autoregulation. As changes in cerebral intravascular oxygenation (HbD), regional cerebral oxygen saturation (rSO(2)), and cerebral tissue oxygenation (TOI) reflect changes in cerebral blood flow (CBF), impaired autoregulation can be measured by studying the concordance between HbD/rSO(2)/TOI and the mean arterial blood pressure (MABP), assuming no changes in oxygen consumption, arterial oxygen saturation (SaO(2)), and in blood volume. We investigated the performance of the partial coherence (PCOH) method, and compared it with the coherence method (COH). The PCOH method allows the elimination of the influence of SaO(2) on HbD/rSO(2)/TOI in a linear way. We started from long-term recordings measured in the first days of life simultaneously in 30 infants from three medical centres. We then compared the COH and PCOH results with patient clinical characteristics and outcomes, and concluded that PCOH might be a better method for assessing impaired autoregulation. |
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Authors:
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D De Smet; J Jacobs; L Ameye; J Vanderhaegen; G Naulaers; P Lemmers; F van Bel; M Wolf; S Van Huffel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Advances in experimental medicine and biology Volume: 662 ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-03-05 Completed Date: 2010-03-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: United States |
Other Details:
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Languages: eng Pagination: 219-24 Citation Subset: IM |
Affiliation:
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Department of Electrical Engineering (ESAT), SCD Division, Katholieke Universiteit Leuven, Leuven, Belgium. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Brain
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physiopathology* Homeostasis / physiology* Humans Infant, Newborn Infant, Premature Netherlands Oxygen / metabolism Spectroscopy, Near-Infrared / methods* Switzerland |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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