| Parthenolide induces significant apoptosis and production of reactive oxygen species in high-risk pre-B leukemia cells. | |
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MedLine Citation:
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PMID: 17470383 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated whether parthenolide, the principal bioactive component of the herb feverfew (Tanacetum parthenium) induced apoptosis in pre-B acute lymphoblastic leukemia (ALL) lines, including cells carrying the t(4;11)(q21;q23) chromosomal translocation. Parthenolide induced rapid apoptotic cell death distinguished by loss of nuclear DNA, externalization of cell membrane phosphatidylserine, and depolarization of mitochondrial membranes at concentrations ranging from 5 to 100 microM. Using reactive oxygen species (ROS)-specific dyes, an increase in nitric oxide and superoxide anion was detected in the cells by 4 h after exposure to parthenolide. Parthenolide-induced elevation of hypochlorite anion was observed only in the two t(4;11) lines. These data suggest parthenolide may have potential as a potent and novel therapeutic agent against pre-B ALLs. |
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Authors:
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Susan J Zunino; Jonathan M Ducore; David H Storms |
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Publication Detail:
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Type: Journal Article Date: 2007-04-30 |
Journal Detail:
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Title: Cancer letters Volume: 254 ISSN: 0304-3835 ISO Abbreviation: Cancer Lett. Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-07-30 Completed Date: 2007-09-11 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 119-27 Citation Subset: IM |
Affiliation:
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United States Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, University of California, Davis, CA 95616, USA. szunino@whnrc.usda.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Apoptosis
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drug effects* Dose-Response Relationship, Drug Flow Cytometry Humans Membrane Potential, Mitochondrial / drug effects Nitric Oxide / metabolism Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / metabolism, pathology Reactive Oxygen Species / metabolism* Risk Factors Sesquiterpenes / pharmacology* Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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0/Reactive Oxygen Species; 0/Sesquiterpenes; 10102-43-9/Nitric Oxide; 29552-41-8/parthenolide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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