| Part-per-trillion determination of pharmaceuticals, pesticides, and related organic contaminants in river water by solid-phase extraction followed by comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry. | |
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MedLine Citation:
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PMID: 20038094 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An analytical procedure based on comprehensive two-dimensional gas chromatography (GC x GC) coupled with time-of-flight mass spectrometry (TOF-MS) for the simultaneous determination of 97 organic contaminants at trace concentration in river water is presented. The target analytes included 13 pharmaceuticals, 18 plasticizers, 8 personal care products, 9 acid herbicides, 8 triazines, 10 organophosphorous compounds, 5 phenylureas, 12 organochlorine biocides, 9 polycyclic aromatic hydrocarbons (PAHs), and 5 benzothiazoles and benzotriazoles. The best resolution of the target analytes in the contour plots was obtained when a nonpolar stationary phase was used in the first dimension and polar one in the second. However, in the opposite configuration, polar-nonpolar, the retention time in the second dimension exhibited a strong correlation with the log Kow (p < 0.01), and it was proposed as an additional identification criteria. The developed methodology is based on a polymeric solid-phase extraction followed by in GC-port methylation and GC x GC/TOF-MS determination. Moreover, limits of detection (LODs) and quantification (LOQs) ranged from 0.5 to 100 ng/L and from 2 to 185 ng/L, respectively. Repeatability was always lower than 20%. Finally, the developed method has been successfully applied to the determination of incurred target analytes in four river waters subjected to a different anthropogenic pressure. |
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Authors:
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V?ctor Matamoros; Eric Jover; Josep M Bayona |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Analytical chemistry Volume: 82 ISSN: 1520-6882 ISO Abbreviation: Anal. Chem. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-14 Completed Date: 2010-03-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370536 Medline TA: Anal Chem Country: United States |
Other Details:
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Languages: eng Pagination: 699-706 Citation Subset: IM |
Affiliation:
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Department of Chemistry, University of Girona, Campus Montilivi, E-17071 Girona, Spain. victor.matamoros@udg.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Environmental Monitoring Gas Chromatography-Mass Spectrometry / methods* Limit of Detection Pesticides / analysis*, chemistry, isolation & purification Pharmaceutical Preparations / analysis*, chemistry, isolation & purification Rivers / chemistry* Solid Phase Extraction / methods* Water Pollutants, Chemical / analysis*, chemistry, isolation & purification |
| Chemical | |
Reg. No./Substance:
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0/Pesticides; 0/Pharmaceutical Preparations; 0/Water Pollutants, Chemical |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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