| Pars plana vitrectomy in eyes containing a treated posterior uveal melanoma. | |
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MedLine Citation:
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PMID: 12967800 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To determine the safety of pars plana vitrectomy in eyes containing a treated posterior uveal melanoma. DESIGN: Interventional case series. METHODS: Retrospective case series of patients with posterior uveal melanoma who underwent pars plana vitrectomy. Complications, vitreous cytology, local tumor control, and metastasis were assessed. RESULTS: Nine patients met study criteria. Tumors were treated with (125)I plaque radiotherapy (seven patients) or transpupillary thermotherapy (two patients). Vitrectomy was performed for vitreous hemorrhage (five patients), macular pucker (two patients), macular hole (one patient), and rhegmatogenous retinal detachment (one patient). Vitrectomy was performed at a mean of 24.7 months (range, 7-47 months) after melanoma treatment. Dispersion of tumor cells at vitrectomy was not observed in any patients. Melanoma cells were detected in the vitreous aspirate in one of seven cases examined cytologically. This patient had intratumoral and vitreous hemorrhage before plaque radiotherapy, underwent combined vitrectomy/cataract extraction, and developed intraocular tumor dissemination 56 months after vitrectomy. No other patients developed intraocular tumor dissemination. At mean follow-up of 24 months (range, 3-63 months) after vitrectomy, none of the nine patients developed systemic metastasis. CONCLUSIONS: Pars plana vitrectomy rarely may lead to intraocular tumor dissemination, although the risk of this complication is probably low if the tumor has been treated and has responded to therapy before vitrectomy. Vitrectomy should be approached with caution if a vitreous hemorrhage is present, especially if the hemorrhage occurred before tumor treatment, as this may seed tumor cells into the vitreous cavity. |
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Authors:
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William J Foster; J William Harbour; Nancy M Holekamp; Gaurav K Shah; Matthew A Thomas |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: American journal of ophthalmology Volume: 136 ISSN: 0002-9394 ISO Abbreviation: Am. J. Ophthalmol. Publication Date: 2003 Sep |
Date Detail:
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Created Date: 2003-09-11 Completed Date: 2003-09-22 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370500 Medline TA: Am J Ophthalmol Country: United States |
Other Details:
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Languages: eng Pagination: 471-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, and Barnes Retina Institute, St. Louis, Missouri 63110, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Brachytherapy Female Humans Hyperthermia, Induced Male Melanoma / complications, therapy* Middle Aged Neoplasm Metastasis Retinal Diseases / complications, surgery* Retrospective Studies Safety Uveal Neoplasms / complications, therapy* Vitrectomy* Vitreous Hemorrhage / complications, surgery* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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