| Parp and cell death or protection in rat primary astroglial cell cultures under LPS/IFNgamma induced proinflammatory conditions. | |
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MedLine Citation:
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PMID: 18758954 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The enzyme poly(ADP-ribose)polymerase (PARP) has a leader role in the DNA damage survey mechanisms by its nick-sensor function, but it is also involved in the early events of the programmed cell death, particularly during inflammatory injury, as a coactivator of NF-kB. In the present study, we evaluated the PARP involvement in the mechanisms of protection and/or cell death in rat astroglial cell cultures during the early phase of proinflammatory commitment after lipopolysaccharide and interferon gamma treatment. According with the recent findings that PARP-1 phosphorylation by MAPK/ERK-2 pathway seems to modulate PARP activation, in time course experiments we demonstrated that a very early PARP activation and expression is able to trigger a cell death pathway, DNA damage independent, during strong proinflammatory insults, maintaining its role of guardian of the genome stability only during the normal cell cycling. |
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Authors:
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V Spina-Purrello; D Patti; A M Giuffrida-Stella; V G Nicoletti |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-08-29 |
Journal Detail:
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Title: Neurochemical research Volume: 33 ISSN: 1573-6903 ISO Abbreviation: Neurochem. Res. Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-11-17 Completed Date: 2009-02-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7613461 Medline TA: Neurochem Res Country: United States |
Other Details:
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Languages: eng Pagination: 2583-92 Citation Subset: IM |
Affiliation:
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Department of Chemical Sciences, Section of Biochemistry and Molecular Biology, Medical Faculty, University of Catania, Viale A. Doria 6, 95125, Catania, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Astrocytes / cytology*, drug effects, enzymology Blotting, Western Cell Death* Cell Line Interferon-gamma / pharmacology L-Lactate Dehydrogenase / metabolism Lipopolysaccharides / pharmacology Poly(ADP-ribose) Polymerases / metabolism* Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Lipopolysaccharides; 82115-62-6/Interferon-gamma; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 2.4.2.30/Poly(ADP-ribose) Polymerases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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