Document Detail

Paroxysmal nocturnal hemoglobinuria and acute non-lymphocytic leukemia. A report of three cases exhibiting different cytologic types.
MedLine Citation:
PMID:  6839299     Owner:  NLM     Status:  MEDLINE    
Three individuals with paroxysmal nocturnal hemoglobinuria (PNH) developed acute non-lymphocytic leukemia (ANLL) as a terminal event. The cytologic types were different in each case suggesting a transformation that may involve a pleuripotent stem cell. Eight previous cases of PNH terminating in acute leukemia have been reported which have also been ANLL in type. Whether PNH should be considered a myelodysplastic or myeloproliferative disorder remains to be seen. PNH has been considered a clonal disorder with several populations of erythrocytes being present. Cytogenetics in the current cases failed to reveal any karyotypic abnormalities during the time PNH was present. However, an abnormal clone appeared in two cases during the time leukemia supervened. Additional studies of PNH as a postulated clonal disorder may provide interesting knowledge for this uncommon disorder.
J R Krause
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cancer     Volume:  51     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1983 Jun 
Date Detail:
Created Date:  1983-06-17     Completed Date:  1983-06-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2078-82     Citation Subset:  AIM; IM    
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MeSH Terms
Acute Disease
Bone Marrow / pathology
Chromosome Aberrations
Hemoglobinuria, Paroxysmal / complications*,  genetics,  pathology
Leukemia / complications*,  genetics
Middle Aged

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