Document Detail


Paroxetine in human breast milk and nursing infants.
MedLine Citation:
PMID:  10671385     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The purpose of this study was to determine the extent of infant medication exposure through breast-feeding during maternal treatment with paroxetine. METHOD: Breast milk and paired maternal and infant sera were collected after 10 days of maternal treatment with paroxetine at a stable daily dose (10-50 mg/day). All samples were analyzed by means of high-performance liquid chromatography with ultraviolet detection and a limit of detection of 2 ng/ml. RESULTS: Breast milk paroxetine concentrations were highly variable (2-101 ng/ml) and were present in all breast milk samples (N=108). A significant gradient effect was observed, with greater paroxetine concentrations found in later portions of breast milk (hind milk) than in early portions (fore milk). No clear time course of paroxetine excretion into breast milk was demonstrated, although maternal paroxetine daily dose reliably predicted both trough and peak breast milk concentrations over a 24-hour period. In 16 mother and infant serum pairs, no detectable concentrations of paroxetine were found in the serum of the nursing infants. CONCLUSIONS: This study extends previous data by demonstrating the presence of paroxetine in the breast milk of nursing women treated with this medication. The low concentrations of paroxetine in infant serum and lack of any observable adverse effects after maternal use of this medication while breast-feeding parallels the available data on other selective serotonin reuptake inhibitors.
Authors:
Z N Stowe; L S Cohen; A Hostetter; J C Ritchie; M J Owens; C B Nemeroff
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of psychiatry     Volume:  157     ISSN:  0002-953X     ISO Abbreviation:  Am J Psychiatry     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-02-29     Completed Date:  2000-02-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370512     Medline TA:  Am J Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  185-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA.
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MeSH Terms
Descriptor/Qualifier:
Breast Feeding*
Chromatography, High Pressure Liquid
Depressive Disorder / drug therapy*,  metabolism
Dose-Response Relationship, Drug
Drug Administration Schedule
Female
Humans
Infant, Newborn / blood*
Milk, Human / chemistry*
Paroxetine / analysis*,  pharmacokinetics,  therapeutic use*
Pregnancy
Puerperal Disorders / drug therapy,  metabolism
Grant Support
ID/Acronym/Agency:
MH-51761/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
61869-08-7/Paroxetine
Comments/Corrections
Comment In:
Am J Psychiatry. 2001 Jan;158(1):144-5   [PMID:  11136654 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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