| Parotid lymph-node metastases from cutaneous squamous-cell carcinomas: treatment outcome and prognostic factors following surgery and adjuvant radiotherapy. | |
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MedLine Citation:
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PMID: 12060157 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Australia has the highest incidence of cutaneous squamous cell carcinoma (SCC) in the world. The majority of lesions occur in the head and neck, and regional lymph-node metastases from cutaneous SCCs, though uncommon, reflect an aggressive manifestation. Surgery and adjuvant radiotherapy are currently considered best practice. Fifty-two eligible patients during 1980-1997 were identified in a retrospective review of patients treated within the department of Radiation Oncology, Westmead Hospital, Sydney. Relevant data were extracted from the files, referring clinicians and the New South Wales Cancer Council. The median age at diagnosis was 63 years and the majority were men (87%). Unfavourable pathological features were present in many of the patients. Only extranodal spread (P = 0.02) was identified as an independent predictor for locoregional recurrence on multivariate analysis. The cumulative locoregional recurrence rates were 28 and 45% at 2 and 5 years, respectively. The 5-year cause-specific survival rate in this study was 65%. We conclude that parotid lymph-node metastases from cutaneous SCCs of the head and neck are associated with a high rate of locoregional recurrence and cause-specific mortality despite surgery and adjuvant radiotherapy. The role of altered fractionation after surgery as a means to further enhance locoregional control warrants further investigation. |
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Authors:
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Margaret S-T Chua; Michael J Veness; Gary Morgan; Thomas Shakespeare; Andrew Hehir; Val Gebski; Burcu Cakir; Kenneth W Tiver |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Australasian radiology Volume: 46 ISSN: 0004-8461 ISO Abbreviation: Australas Radiol Publication Date: 2002 Jun |
Date Detail:
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Created Date: 2002-06-12 Completed Date: 2002-08-22 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0047441 Medline TA: Australas Radiol Country: Australia |
Other Details:
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Languages: eng Pagination: 174-9 Citation Subset: IM |
Affiliation:
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Joint Radiation Oncology Centre, Westmead and Nepean Hospitals, Westmead, Sydney, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Carcinoma, Squamous Cell / radiotherapy, secondary*, surgery Female Head and Neck Neoplasms / pathology, radiotherapy*, surgery* Humans Lymph Nodes / pathology*, surgery Lymphatic Metastasis / radiotherapy Male Middle Aged Neoplasm Recurrence, Local Parotid Gland / surgery Radiotherapy, Adjuvant Survival Analysis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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