Document Detail


Parkinson's disease: the treatment of drug-induced hallucinations and psychosis.
MedLine Citation:
PMID:  11898537     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Drug-induced psychosis is one of the most disabling complications of advancing Parkinson's disease. It has also been one of the most difficult to treat. Clozapine was the first medication shown to be safe and effective in this setting, and it remains the standard by which newer atypical antipsychotics are measured. However, due to the small but significant risk of agranulocytosis and the need for frequent blood testing, alternatives have been sought. Risperidone, olanzapine, and quetiapine are new atypical antipsychotics that have each been proposed as an alternative to clozapine, but the literature concerning their use in Parkinson's disease is conflicted and confusing. Although quetiapine appears to be the best current choice, none of these medications have equaled clozapine's ability to safely treat drug-induced psychosis without the risk of worsening parkinsonism.
Authors:
E S Molho; S A Factor
Related Documents :
10974607 - Effects of antipsychotic drugs on cholecystokinin and preprotachykinin (substance p) mr...
25377177 - The global consortium for drug-resistant tuberculosis diagnostics (gcdd): design of a m...
8099137 - Antipsychotic drug exposure in a health maintenance organization.
2885367 - A controlled clinical trial of tiaspirone in schizophrenia.
2310887 - Management of the pregnant opiate user.
16203377 - What does mathematical modeling tell us about harm reduction?
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current neurology and neuroscience reports     Volume:  1     ISSN:  1528-4042     ISO Abbreviation:  Curr Neurol Neurosci Rep     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2002-03-18     Completed Date:  2002-04-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100931790     Medline TA:  Curr Neurol Neurosci Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  320-8     Citation Subset:  IM    
Affiliation:
Parkinson's Disease and Movement Disorder Center, Albany Medical Center, 215 Washington Ave. Extension, Albany, NY 12203, USA. molhoe@mail.amc.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Antipsychotic Agents / therapeutic use
Hallucinations / chemically induced*,  drug therapy*
Humans
Parkinson Disease / drug therapy*,  psychology
Psychoses, Substance-Induced / drug therapy*
Chemical
Reg. No./Substance:
0/Antipsychotic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Parkinson's disease: surgical options.
Next Document:  Initial treatment of early Parkinson's disease: a review of recent, randomized controlled trials.