Document Detail

Parkinson's disease: the treatment of drug-induced hallucinations and psychosis.
MedLine Citation:
PMID:  11898537     Owner:  NLM     Status:  MEDLINE    
Drug-induced psychosis is one of the most disabling complications of advancing Parkinson's disease. It has also been one of the most difficult to treat. Clozapine was the first medication shown to be safe and effective in this setting, and it remains the standard by which newer atypical antipsychotics are measured. However, due to the small but significant risk of agranulocytosis and the need for frequent blood testing, alternatives have been sought. Risperidone, olanzapine, and quetiapine are new atypical antipsychotics that have each been proposed as an alternative to clozapine, but the literature concerning their use in Parkinson's disease is conflicted and confusing. Although quetiapine appears to be the best current choice, none of these medications have equaled clozapine's ability to safely treat drug-induced psychosis without the risk of worsening parkinsonism.
E S Molho; S A Factor
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current neurology and neuroscience reports     Volume:  1     ISSN:  1528-4042     ISO Abbreviation:  Curr Neurol Neurosci Rep     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2002-03-18     Completed Date:  2002-04-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100931790     Medline TA:  Curr Neurol Neurosci Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  320-8     Citation Subset:  IM    
Parkinson's Disease and Movement Disorder Center, Albany Medical Center, 215 Washington Ave. Extension, Albany, NY 12203, USA.
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MeSH Terms
Antipsychotic Agents / therapeutic use
Hallucinations / chemically induced*,  drug therapy*
Parkinson Disease / drug therapy*,  psychology
Psychoses, Substance-Induced / drug therapy*
Reg. No./Substance:
0/Antipsychotic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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