| Parkinson's disease and systemic inflammation. | |
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MedLine Citation:
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PMID: 21403862 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Peripheral inflammation triggers exacerbation in the central brain's ongoing damage in several neurodegenerative diseases. Systemic inflammatory stimulus induce a general response known as sickness behaviour, indicating that a peripheral stimulus can induce the synthesis of cytokines in the brain. In Parkinson's disease (PD), inflammation was mainly associated with microglia activation that can underlie the neurodegeneration of neurons in the substantia nigra (SN). Peripheral inflammation can transform the "primed" microglia into an "active" state, which can trigger stronger responses dealing with neurodegenerative processes. Numerous evidences show that systemic inflammatory processes exacerbate ongoing neurodegeneration in PD patient and animal models. Anti-inflammatory treatment in PD patients exerts a neuroprotective effect. In the present paper, we analyse the effect of peripheral infections in the etiology and progression in PD patients and animal models, suggesting that these peripheral immune challenges can exacerbate the symptoms in the disease. |
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Authors:
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Carina C Ferrari; Rodolfo Tarelli |
Publication Detail:
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Type: Journal Article Date: 2011-02-22 |
Journal Detail:
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Title: Parkinson's disease Volume: 2011 ISSN: 2042-0080 ISO Abbreviation: Parkinsons Dis Publication Date: 2011 |
Date Detail:
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Created Date: 2011-03-15 Completed Date: 2011-07-14 Revised Date: 2011-07-26 |
Medline Journal Info:
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Nlm Unique ID: 101539877 Medline TA: Parkinsons Dis Country: England |
Other Details:
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Languages: eng Pagination: 436813 Citation Subset: - |
Affiliation:
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Laboratorio de Terapias Regenerativas y Protectoras del Sistema Nervioso, Fundación Instituto Leloir, Patricias Argentinas 435, C1405BWE Buenos Aires, Argentina. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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