| Parkinson's disease spatial covariance pattern: noninvasive quantification with perfusion MRI. | |
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MedLine Citation:
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PMID: 20051975 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Parkinson's disease (PD) is associated with elevated expression of a specific disease-related spatial covariance pattern (PDRP) in radiotracer scans of cerebral blood flow and metabolism. In this study, we scanned nine early-stage patients with PD and nine healthy controls using continuous arterial spin labeling (CASL) perfusion magnetic resonance imaging (pMRI). Parkinson's disease-related metabolic pattern expression in CASL pMRI scans was compared with the corresponding (18)F-fluorodeoxyglucose positron emission tomography values. The PDRP expression was abnormally elevated (P<0.01) in patients scanned with either modality, and the two values were highly intercorrelated (P<0.0001). Perfusion MRI methods can be used for accurate quantification of disease-related covariance patterns. |
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Authors:
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Yilong Ma; Chaorui Huang; Jonathan P Dyke; Hong Pan; David Alsop; Andrew Feigin; David Eidelberg |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-01-06 |
Journal Detail:
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Title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Volume: 30 ISSN: 1559-7016 ISO Abbreviation: J. Cereb. Blood Flow Metab. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-02 Completed Date: 2010-04-02 Revised Date: 2011-07-25 |
Medline Journal Info:
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Nlm Unique ID: 8112566 Medline TA: J Cereb Blood Flow Metab Country: United States |
Other Details:
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Languages: eng Pagination: 505-9 Citation Subset: IM |
Affiliation:
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Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, New York 11030, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Brain Chemistry / physiology Cerebrovascular Circulation Data Interpretation, Statistical Female Fluorodeoxyglucose F18 / diagnostic use Humans Magnetic Resonance Imaging Male Middle Aged Parkinson Disease / pathology*, radionuclide imaging* Pilot Projects Positron-Emission Tomography Radiopharmaceuticals / diagnostic use |
| Grant Support | |
ID/Acronym/Agency:
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M01 RR018535/RR/NCRR NIH HHS; M01 RR018535-05/RR/NCRR NIH HHS; M01 RR018535-06/RR/NCRR NIH HHS; M01 RR018535-07/RR/NCRR NIH HHS; M01 RR018535-08/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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