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Parkinson's disease progression: implicit acquisition, cognitive and motor impairments, and medication effects.
MedLine Citation:
PMID:  22907996     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Parkinson's disease (PD) symptoms have been collectively ascribed to malfunctioning of dopamine-related nigro-striatal and cortico-striatal loops. However, some doubts about this proposition are raised by controversies about the temporal progression of the impairments, and whether they are concomitant or not. The present study consists of a systematic revision of literature data on both functional PD impairments and dopaminergic medication effects in order to draw a coherent picture about the disease progression. It was done in terms of an explanatory model for the disruption of implicit knowledge acquisition, motor and cognitive impairments, and the effects of dopaminergic medication on these functions. Cognitive impairments arise at early stages of PD and stabilizes while disruption of implicit knowledge acquisition and motor impairments, are still in progression; additionally, dopaminergic medication reduces motor impairments and increases disruption of implicit knowledge acquisition. Since this model revealed consistency and plausibility when confronted with data of others studies not included in model's formulation, it may turn out to be a useful tool for understanding the multifaceted characteristics of PD.
Authors:
Rodrigo Pavão; André Frazão Helene; Gilberto Fernando Xavier
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Publication Detail:
Type:  Journal Article     Date:  2012-08-10
Journal Detail:
Title:  Frontiers in integrative neuroscience     Volume:  6     ISSN:  1662-5145     ISO Abbreviation:  Front Integr Neurosci     Publication Date:  2012  
Date Detail:
Created Date:  2012-08-21     Completed Date:  2012-10-02     Revised Date:  2013-08-13    
Medline Journal Info:
Nlm Unique ID:  101477950     Medline TA:  Front Integr Neurosci     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  56     Citation Subset:  -    
Affiliation:
Biosciences Institute, University of São Paulo São Paulo, Brazil.
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