Document Detail


Parkinson's disease, pesticides, and glutathione transferase polymorphisms.
MedLine Citation:
PMID:  9802272     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Parkinson's disease is thought to be secondary to the presence of neurotoxins, and pesticides have been implicated as possible causative agents. Glutathione transferases (GST) metabolise xenobiotics, including pesticides. Therefore, we investigated the role of GST polymorphisms in the pathogenesis of idiopathic Parkinson's disease. METHODS: We genotyped by PCR polymorphisms in four GST classes (GSTM1, GSTT1, GSTP1, and GSTZ1) in 95 Parkinson's disease patients and 95 controls. We asked all patients for information about pesticide exposure. FINDINGS: The distribution of the GSTP1 genotypes differed significantly between patients and controls who had been exposed to pesticides (controls vs patients: AA 14 [54%] of 26 vs seven [18%] of 39; AB 11 [42%] of 26 vs 22 [56%] of 39; BB 1 [4%] of 26 vs six [15%] of 39; AC 0 vs four [10%] of 39, p=0.009). No association was found with any of the other GST polymorphisms. Pesticide exposure and a positive family history were risk factors for Parkinson's disease. INTERPRETATION: GSTP1-1, which is expressed in the blood-brain barrier, may influence response to neurotoxins and explain the susceptibility of some people to the parkinsonism-inducing effects of pesticides.
Authors:
A Menegon; P G Board; A C Blackburn; G D Mellick; D G Le Couteur
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lancet     Volume:  352     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1998-11-17     Completed Date:  1998-11-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1344-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Pharmacology, University of Sydney, Canberra Clinical School, The Canberra Hospital, Australia.
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MeSH Terms
Descriptor/Qualifier:
Aged
Australia
Blood-Brain Barrier / drug effects
Case-Control Studies
Environmental Exposure / adverse effects
Female
Genotype
Glutathione Transferase / classification,  genetics*
Humans
Logistic Models
Male
Middle Aged
Parkinson Disease, Secondary / chemically induced*,  genetics*
Pesticides / adverse effects*
Polymorphism, Genetic
Questionnaires
Chemical
Reg. No./Substance:
0/Pesticides; EC 2.5.1.18/Glutathione Transferase
Comments/Corrections
Comment In:
Lancet. 1999 Jan 2;353(9146):71-2   [PMID:  10023978 ]
Lancet. 1998 Oct 24;352(9137):1328-9   [PMID:  9802266 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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