Document Detail


Parkinson's Disease Mild Cognitive Impairment: Application and Validation of the Criteria.
MedLine Citation:
PMID:  24296865     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Dementia in Parkinson's disease (PD) is a serious health issue and a major concern for many patients. In most cases mild cognitive impairment (MCI) is considered a transitional stage between normal cognitive functioning and dementia which is of potential importance in the early identification of patients at risk for dementia. Recently, the Movement Disorder Society (MDS) proposed diagnostic criteria for MCI in PD (PD-MCI). These criteria comprise two operationalizations: Level I (based on an abbreviated assessment) and Level II (based on comprehensive neuropsychological evaluation permitting MCI subtyping). These criteria need to be validated. This paper describes a project aiming to validate the MDS PD-MCI criteria by pooling and analyzing cross-sectional and longitudinal neuropsychological databases comprising ≥5,500 PD patients and ≥1,700 controls. After applying the MDS PD-MCI Level I and Level II criteria, rates of conversion to PD-dementia and predictive variables for conversion to PD-dementia will be established. This study will also assist in identifying whether revisions of the PD-MCI criteria are required.
Authors:
Gert J Geurtsen; Jeroen Hoogland; Jennifer G Goldman; Ben A Schmand; Alexander I Trőster; David J Burn; Irene Litvan
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-12-2
Journal Detail:
Title:  Journal of Parkinson's disease     Volume:  -     ISSN:  1877-718X     ISO Abbreviation:  J Parkinsons Dis     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2013-12-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101567362     Medline TA:  J Parkinsons Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Neurology, Academic Medical Center Amsterdam, The Netherlands.
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