Document Detail

Parkinsonism with HIV infection.
MedLine Citation:
PMID:  9686775     Owner:  NLM     Status:  MEDLINE    
We describe six patients with parkinsonism and another 10 patients with parkinsonian features with human immunodeficiency virus (HIV) infection. In 50% of these patients, the symptoms were precipitated by neuroleptics. In the remaining patients, no obvious cause other than HIV infection was identified. Discontinuation of the neuroleptics produced complete recovery in one patient and partial or no response in others. Rapid progression of parkinsonism was noted in two patients, one of whom was treated with high-dose zidovudine (AZT) and benztropine. We conclude that patients with AIDS are at risk of developing an akinetic parkinsonism which may be precipitated by the use of neuroleptics, response to treatment is variable, and parkinsonism may be another primary HIV-induced syndrome.
S M Mirsattari; C Power; A Nath
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  13     ISSN:  0885-3185     ISO Abbreviation:  Mov. Disord.     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-10-28     Completed Date:  1998-10-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  684-9     Citation Subset:  IM; X    
Department of Internal Medicine, University of Manitoba, Winnipeg, Canada.
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MeSH Terms
AIDS Dementia Complex / diagnosis,  drug therapy*
AIDS-Related Opportunistic Infections / diagnosis,  drug therapy
Anti-HIV Agents / adverse effects,  therapeutic use
Antipsychotic Agents / adverse effects*
Benztropine / adverse effects,  therapeutic use
Drug Therapy, Combination
HIV Infections / diagnosis,  drug therapy*
Homosexuality, Male
Neurologic Examination / drug effects
Parkinson Disease, Secondary / chemically induced*,  diagnosis
Risk Factors
Zidovudine / adverse effects,  therapeutic use
Reg. No./Substance:
0/Anti-HIV Agents; 0/Antipsychotic Agents; 30516-87-1/Zidovudine; 86-13-5/Benztropine
Comment In:
Mov Disord. 2000 Sep;15(5):1032-3   [PMID:  11009225 ]

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