Document Detail

Parkinsonism produced by tetrahydroisoquinoline (TIQ) or the analogues.
MedLine Citation:
PMID:  8093578     Owner:  NLM     Status:  MEDLINE    
The effect of chronic administration of a probable endogenous dopaminergic neurotoxin, tetrahydroisoquinoline, has been examined on squirrel monkeys. Chronically administered TIQ produced motor symptoms similar to parkinsonism in squirrel monkeys even 7 days after discontinuation of TIQ and the symptoms were alleviated remarkably by L-DOPA treatment. Biochemical analysis of the brains of TIQ-treated monkeys revealed significant decrease in dopamine (DA) and total biopterin (BP) concentrations, and tyrosine hydroxylase (TH) activity in the substantia nigra. Morphological changes of the substantia nigra of mice were also analyzed. The effect of long-term administration of N-methyl-TIQ, N-methyl-TIQ+, and N-methyl-norsalsolinol on aged monkeys was described.
M Yoshida; M Ogawa; K Suzuki; T Nagatsu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Advances in neurology     Volume:  60     ISSN:  0091-3952     ISO Abbreviation:  Adv Neurol     Publication Date:  1993  
Date Detail:
Created Date:  1993-02-11     Completed Date:  1993-02-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0367524     Medline TA:  Adv Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  207-11     Citation Subset:  IM    
Department of Neurology, Jichi Medical School, Tochigi, Japan.
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MeSH Terms
Biopterin / physiology
Caudate Nucleus / drug effects,  pathology,  physiopathology
Dopamine / physiology
Isoquinolines / toxicity*
Levodopa / pharmacology
Neurons / drug effects,  pathology,  physiology
Parkinson Disease, Secondary / chemically induced*,  pathology,  physiopathology
Putamen / drug effects,  pathology,  physiopathology
Structure-Activity Relationship
Substantia Nigra / drug effects*,  pathology,  physiopathology
Tyrosine 3-Monooxygenase / physiology
Reg. No./Substance:
0/Isoquinolines; 0/Levodopa; 0/Tetrahydroisoquinolines; 22150-76-1/Biopterin; 4965-09-7/1-methyl-1,2,3,4-tetrahydroisoquinoline; 91-21-4/1,2,3,4-tetrahydroisoquinoline; EC 3-Monooxygenase

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