Document Detail


Parkinsonism-dementia complex of Guam.
MedLine Citation:
PMID:  16092098     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
On Guam and in two other Pacific locales, indigenous residents and immigrants are prone to familial neurodegeneration that manifests as atypical parkinsonism, dementia, motor neuron disease, or a combination of these three phenotypes. This progressive and fatal disease of the Mariana islands, the Kii peninsula of Japan, and the coastal plain of West New Guinea is similar and the pathological features have close affiliation with universal tauopathies, including progressive supranuclear palsy, Alzheimer's disease, and amyotrophic lateral sclerosis. The Chamorros of Guam call the disease lytico-bodig, and neuroscientists refer to it as the amyotrophic lateral sclerosis/Parkinsonism-dementia complex. During recent decades, its prevalence has declined progressively, and the age at onset has steadily increased. In 2004, motor neuron disease, once 100 times more common than elsewhere is rare, atypical parkinsonism is declining, and only dementia remains unusually common in elderly females. The cause of this obscure malady remains uncertain, despite 60 years of international research, but its ending implicates environmental influences rather than genetic predisposition.
Authors:
John C Steele
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  20 Suppl 12     ISSN:  0885-3185     ISO Abbreviation:  Mov. Disord.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-08-15     Completed Date:  2005-12-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S99-S107     Citation Subset:  IM    
Copyright Information:
Copyright 2005 Movement Disorder Society.
Affiliation:
Micronesian Health Study II, Tamuning, Guam. jsteele@kuentos.guam.net
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MeSH Terms
Descriptor/Qualifier:
Age of Onset
Amyotrophic Lateral Sclerosis / genetics,  pathology
Comorbidity
Dementia / epidemiology*,  genetics,  pathology
Guam / epidemiology
Neurofibrillary Tangles / pathology
Parkinsonian Disorders / epidemiology*,  genetics,  pathology
Pedigree
Supranuclear Palsy, Progressive / epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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