Document Detail


Parkinsonism after chronic exposure to the fungicide maneb (manganese ethylene-bis-dithiocarbamate).
MedLine Citation:
PMID:  7801076     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Permanent parkinsonism was observed in a man with chronic exposure to the fungicide maneb (manganese ethylene-bis-dithiocarbamate). Symptoms developed at 37 years of age, two years after exposure had ceased. To our knowledge, this is the second report on parkinsonism associated with exposure to maneb. Manganese is a well-known parkinsonigen toxin in humans. More recently, it has been shown that dithiocarbamates can also induce extrapyramidal syndromes. The biochemical effects of manganese and dithiocarbamates are reviewed and their possible neurotoxic mechanisms are discussed. Both of these components may have played a role in this case.
Authors:
G Meco; V Bonifati; N Vanacore; E Fabrizio
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of work, environment & health     Volume:  20     ISSN:  0355-3140     ISO Abbreviation:  Scand J Work Environ Health     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1995-01-26     Completed Date:  1995-01-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7511540     Medline TA:  Scand J Work Environ Health     Country:  FINLAND    
Other Details:
Languages:  eng     Pagination:  301-5     Citation Subset:  IM    
Affiliation:
Department of Neurosciences, La Sapienza University, Rome, Italy.
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MeSH Terms
Descriptor/Qualifier:
Humans
Male
Maneb / adverse effects*
Manganese / adverse effects*
Middle Aged
Occupational Exposure / adverse effects*
Parkinson Disease, Secondary / chemically induced*
Chemical
Reg. No./Substance:
12427-38-2/Maneb; 7439-96-5/Manganese

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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