Document Detail


Parkinson disease is not associated with C9ORF72 repeat expansions.
MedLine Citation:
PMID:  23116878     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Hexanucleotide expansions in the C9ORF72 gene are frequently found in patients with amyotrophic lateral sclerosis, frontotemporal dementia or both, some of whom exhibit concurrent extrapyramidal symptoms. To determine if repeat expansions are a cause of Parkinson's disease (PD), we used repeat-primed polymerase chain reaction to investigate the frequency of C9ORF72 repeat expansions in a cohort of 478 patients with PD and 662 control subjects. Three control subjects were found to be expansion carriers, and no expansions were found among patients, suggesting that C9ORF72 expansions are not a common cause of PD.
Authors:
Matthew B Harms; Drexel Neumann; Bruno A Benitez; Breanna Cooper; David Carrell; Brad A Racette; Joel S Perlmutter; Alison Goate; Carlos Cruchaga
Related Documents :
7370378 - Alcohol and marrow granulocyte reserve response to etiocholanolone.
10378138 - Spontaneous non-typhoidal salmonella peritonitis in patients with serious underlying di...
10081618 - Different responses to surgical stress between extra domain a+ and plasma fibronectins.
12423268 - Delayed gastrointestinal transit in patients with hepatocellular carcinoma.
16960458 - Plasma concentrations of tumor necrosis factor alpha may predict the outcome of patient...
21150778 - Clinical predictors for progression of nonintervened nonculprit coronary lesions despit...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-29
Journal Detail:
Title:  Neurobiology of aging     Volume:  -     ISSN:  1558-1497     ISO Abbreviation:  Neurobiol. Aging     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-11-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8100437     Medline TA:  Neurobiol Aging     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Department of Neurology, Washington University School of Medicine, Saint Louis, MO, USA; Department of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  In vivo glutamate measured with magnetic resonance spectroscopy: behavioral correlates in aging.
Next Document:  Preliminary study on the association of AQP4 promoter polymorphism with anti-aquaporin-4 antibody po...