Document Detail

Parity and tanned white skin as novel predictors of vitamin D status in early pregnancy: a population-based cohort study.
MedLine Citation:
PMID:  23305099     Owner:  NLM     Status:  MEDLINE    
CONTEXT: In pregnancy, vitamin D insufficiency and deficiency, defined as serum 25-hydroxyvitamin D (25(OH)D) <50 nM, and <25 nM, respectively, may have adverse effects for both mother and child. Prevalence estimates, and identification of subgroups at special risk, may be useful for the planning of preventive strategies.
OBJECTIVE: To study the prevalence and risk factors of hypovitaminosis D in early pregnancy.
DESIGN AND METHODS: In a cross-sectional study of 1348 women in early pregnancy from the Odense Child Cohort, Denmark, 25(OH)D was determined and correlated to demographic and lifestyle variables (age, nationality, skin tone, parity, prepregnancy body mass index (BMI), smoking and sun exposure), using multiple linear and logistic regression analyses for all year, or stratified for summer and winter. The risk of vitamin D insufficiency was expressed as odds ratios (OR) with 95% confidence intervals in brackets.
RESULTS: The prevalence of vitamin D insufficiency and deficiency was estimated to 27·8% and 3·5% respectively. In adjusted analyses, vitamin D insufficiency was directly associated with winter season, OR = 1·89 (1·35-2·63); increasing prepregnancy BMI, OR = 1·06 (1·03-1·10); and smoking, OR = 2·7 (1·34-5·41); but was less frequent in nulliparous, OR = 0·47 (0·33-0·68) and tanned Caucasians, OR = 0·63 (0·41-0·97). Season-specific associations having parental origin from outside Europe in summer, OR = 4·13 (1·41-12·13); in winter smoking, OR = 3·15 (1·19-8·36); and prepregnancy BMI, OR = 1·12 (1·06-1·18).
CONCLUSIONS: Vitamin D insufficiency was widespread in early pregnancy. Associations to smoking, prepregnancy BMI and origin outside Europe varied with season. Multiparity and not being tanned in Caucasians represent new risk factors of vitamin D insufficiency.
L B Andersen; B Abrahamsen; C Dalgård; H B Kyhl; S S Beck-Nielsen; M Frost-Nielsen; J S Jørgensen; T Barington; H T Christesen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-07-02
Journal Detail:
Title:  Clinical endocrinology     Volume:  79     ISSN:  1365-2265     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-07-24     Completed Date:  2014-02-24     Revised Date:  2014-07-27    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  England    
Other Details:
Languages:  eng     Pagination:  333-41     Citation Subset:  IM    
Copyright Information:
© 2013 John Wiley & Sons Ltd.
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MeSH Terms
Body Mass Index
Cohort Studies
Cross-Sectional Studies
European Continental Ancestry Group
Odds Ratio
Pregnancy Complications
Risk Factors
Vitamin D / analogs & derivatives*,  biosynthesis
Vitamin D Deficiency / blood*,  epidemiology
Young Adult
Reg. No./Substance:
1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D
Comment In:
Clin Endocrinol (Oxf). 2014 Jul;81(1):155-6   [PMID:  24102268 ]
Clin Endocrinol (Oxf). 2014 Jul;81(1):154   [PMID:  24102337 ]

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