Document Detail


Parietal epithelial cell activation marker in early recurrence of FSGS in the transplant.
MedLine Citation:
PMID:  22917699     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND OBJECTIVES: Podocyte loss is key in glomerulosclerosis. Activated parietal epithelial cells are proposed to contribute to pathogenesis of glomerulosclerosis and may serve as stem cells that can transition to podocytes. CD44 is a marker for activated parietal epithelial cells. This study investigated whether activated parietal epithelial cells are increased in early recurrent FSGS in transplant compared with minimal change disease.
DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: CD44 staining in renal allograft biopsies from 12 patients with recurrent FSGS was performed and compared with native kidneys with minimal change disease or FSGS and normal control native and transplant kidneys without FSGS. CD44+ epithelial cells along Bowman's capsule in the parietal epithelial cell location and over the glomerular tuft in the visceral epithelial cell location were assessed.
RESULTS: Cases with early recurrent FSGS manifesting only foot process effacement showed significantly increased CD44+ visceral epithelial cells involving 29.0% versus 2.6% of glomeruli in minimal change disease and 0% in non-FSGS transplants. Parietal location CD44 positivity also was numerically increased in recurrent FSGS. In later transplant biopsies, glomeruli with segmental lesions had more CD44+ visceral epithelial cells than glomeruli without lesions.
CONCLUSIONS: Parietal epithelial cell activation marker is significantly increased in evolving FSGS versus minimal change disease, and this increase may distinguish early FSGS from minimal change disease. Whether parietal epithelial cell activation contributes to pathogenesis of sclerosis in idiopathic FSGS or is a regenerative/repair response to replace injured podocytes awaits additional study.
Authors:
Huma Fatima; Marcus J Moeller; Bart Smeets; Hai-Chun Yang; Vivette D D'Agati; Charles E Alpers; Agnes B Fogo
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Publication Detail:
Type:  Journal Article; Research Support, American Recovery and Reinvestment Act; Research Support, N.I.H., Extramural     Date:  2012-08-23
Journal Detail:
Title:  Clinical journal of the American Society of Nephrology : CJASN     Volume:  7     ISSN:  1555-905X     ISO Abbreviation:  Clin J Am Soc Nephrol     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-08     Completed Date:  2013-06-21     Revised Date:  2013-11-14    
Medline Journal Info:
Nlm Unique ID:  101271570     Medline TA:  Clin J Am Soc Nephrol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1852-8     Citation Subset:  IM    
Affiliation:
Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Antigens, CD44 / analysis
Child
Child, Preschool
Dystroglycans / analysis
Epithelial Cells / pathology*
Female
Glomerulosclerosis, Focal Segmental / diagnosis,  etiology*
Humans
Kidney Transplantation*
Male
Middle Aged
Nephrosis, Lipoid / diagnosis
Podocytes / pathology
Recurrence
Urothelium / pathology*
Grant Support
ID/Acronym/Agency:
DK080095/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, CD44; 0/CD44 protein, human; 0/DAG1 protein, human; 146888-27-9/Dystroglycans
Comments/Corrections

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